LY 2874455

Base Information

• Chemical Name: LY 2874455
• CAS No.: 1254473-64-7
• Molecular Formula: C21H19Cl2N5O2
• Molecular Weight: 444.31
• Mol file: 1254473-64-7.mol

Synonyms:(R)-(E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol;CS-0907;QCR-90;

Chemical Property of LY 2874455

Chemical Property:

• Boiling Point: 672.6±55.0 °C(Predicted)
• PKA: 12.93±0.40(Predicted)
• PSA: 88.85000
• Density: 1.44
• LogP: 4.76390
• Solubility.: ≥44.4 mg/mL in DMSO; insoluble in H2O; ≥6.34 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

98%,99%, ^*data from raw suppliers

LY2874455 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.