3-Bromo-6-methoxypicolinic acid

Base Information

• Chemical Name: 3-Bromo-6-methoxypicolinic acid
• CAS No.: 1196147-56-4
• Molecular Formula: C7H6BrNO3
• Molecular Weight: 232.03144
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90704722
• Wikidata: Q82637232
• Mol file: 1196147-56-4.mol

Synonyms:3-Bromo-6-methoxypicolinic acid;1196147-56-4;3-Bromo-6-methoxypyridine-2-carboxylic acid;3-Bromo-6-methoxypicolinicacid;3-Bromo-6-methoxy-pyridine-2-carboxylic acid;SCHEMBL19206992;DTXSID90704722;AMY39664;WXB14756;MFCD13185812;AKOS015835159;AB66791;DS-17590;CS-0186789;FT-0734641;2-Pyridinecarboxylic acid, 3-bromo-6-methoxy-;C71659;A846912;3-BROMO-6-METHOXY-2-PYRIDINECARBOXYLIC ACID

Chemical Property of 3-Bromo-6-methoxypicolinic acid

Chemical Property:

• PSA: 59.42000
• LogP: 1.55090
• Storage Temp.: Room temperature.
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 230.95311
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-6-methoxypicolinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)Br)C(=O)O

Technology Process of 3-Bromo-6-methoxypicolinic acid

There total 3 articles about 3-Bromo-6-methoxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-6-methoxypicolinonitrile (1186637-43-3) → 3-bromo-6-methoxypicolinic acid (1196147-56-4)

Guidance literature:

With sodium hydroxide; In ethanol; at 100 ℃; for 12h;

Reference yield:

2-methoxyl-5-bromo-pyridine N-oxide (446284-14-6) → 3-bromo-6-methoxypicolinic acid (1196147-56-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 14 h / 100 °C

2: sodium hydroxide / ethanol / 12 h / 100 °C

With triethylamine; sodium hydroxide; In ethanol; acetonitrile;

Reference yield:

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) → 3-bromo-6-methoxypicolinic acid (1196147-56-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 100 °C

2: triethylamine / acetonitrile / 14 h / 100 °C

3: sodium hydroxide / ethanol / 12 h / 100 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; chloroform; acetonitrile;

upstream raw materials:

2-methoxyl-5-bromo-pyridine N-oxide

3-bromo-6-methoxypicolinonitrile

2-methoxy-5-bromopyridine

Refernces