（R）-3-ter-butylamino-1,2-epxoypropane

Base Information

• Chemical Name: （R）-3-ter-butylamino-1,2-epxoypropane
• CAS No.: 98048-85-2
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.202
• Mol file: 98048-85-2.mol

Synonyms:（R）-3-ter-butylamino-1,2-epxoypropane;(R)-3-tert-Butylamino-1,2-Epoxoypropane;(R)-3-tert-ButylaMino-1,2-Epxoypropane;(2R)-N-(1,1-DiMethylethyl)-2-OxiraneMethanaMine

Chemical Property of （R）-3-ter-butylamino-1,2-epxoypropane

Chemical Property:

• Boiling Point: 158.9±13.0 °C(Predicted)
• PKA: 10.01±0.30(Predicted)
• PSA: 24.56000
• Density: 0.921±0.06 g/cm3(Predicted)
• LogP: 1.16420

Purity/Quality:

98%Min ^*data from raw suppliers

(2R)-N-(1,1-Dimethylethyl)-2-Oxiranemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2R)-N-(1,1-Dimethylethyl)-2-Oxiranemethanamine is used in the synthesis of a key intermediate used for the inversion of racemic 2-oxazolidinones.

Technology Process of （R）-3-ter-butylamino-1,2-epxoypropane

There total 4 articles about （R）-3-ter-butylamino-1,2-epxoypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-3-tert-butylamino-2-acetoxy-1-bromopropane hydrobromide → (R)-3-tert-butylamino-1,2-epoxypropane (98048-85-2)

Guidance literature:

With sodium methylate; In methanol; dichloromethane; for 0.5h;

DOI:10.1271/bbb1961.49.1669

Reference yield:

(R)-5-hydroxymethyl-3-tert-butyl-2-oxazolodinone (98048-84-1) → (R)-3-tert-butylamino-1,2-epoxypropane (98048-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / NaOH, H₂O / 15 h / 95 °C

2: 93 percent / HBr / 3 h / Ambient temperature

3: 85 percent / sodium methoxyde / methanol; CH₂Cl₂ / 0.5 h

With sodium hydroxide; water; hydrogen bromide; sodium methylate; In methanol; dichloromethane;

DOI:10.1271/bbb1961.49.1669

Reference yield:

(R,S)-5-hexanoyloxymethyl-3-tert-butyl-oxazolidin-2-one → (R)-3-tert-butylamino-1,2-epoxypropane (98048-85-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 40 percent / lipoprotein lipase Amano 3 adsorbed on Amberlite XAD-7, H₂O / 6 h / 33 °C / pH = 7.0

2: 93 percent / NaOH, H₂O / 15 h / 95 °C

3: 93 percent / HBr / 3 h / Ambient temperature

4: 85 percent / sodium methoxyde / methanol; CH₂Cl₂ / 0.5 h

With sodium hydroxide; lipoprotein lipase Amano 3 adsorbed on Amberlite XAD-7; water; hydrogen bromide; sodium methylate; In methanol; dichloromethane;

DOI:10.1271/bbb1961.49.1669

upstream raw materials:

(R)-5-hydroxymethyl-3-tert-butyl-2-oxazolodinone

(R)-1-tert-butylamino-2,3-dihydroxypropane

Refernces