(2-chloropyridin-3-yl)MethanaMine hydrochloride

Base Information

• Chemical Name: (2-chloropyridin-3-yl)MethanaMine hydrochloride
• CAS No.: 1220039-41-7
• Molecular Formula: C6H7ClN2.2ClH
• Molecular Weight: 179.04712
• Mol file: 1220039-41-7.mol

Synonyms:3-aminomethyl-2-chloropyridine hydrochloride;(2-chloropyridin-3-yl)methanamine hydrochloride;

Chemical Property of (2-chloropyridin-3-yl)MethanaMine hydrochloride

Chemical Property:

• PSA: 38.91000
• LogP: 2.69600

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-chloropyridin-3-yl)MethanaMine hydrochloride

There total 1 articles about (2-chloropyridin-3-yl)MethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.2%

2-chloro-3-carbaldehydepyridine (36404-88-3) → (2-chloropyridin-3-yl)methanamine dihydrochloride (1220039-41-7,1432754-64-7,870064-16-7)

Guidance literature:

2-chloro-3-carbaldehydepyridine; With pyridoxal 5'-phosphate; ω-transaminase from Bacillus megaterium; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

Reference yield:

(2-chloropyridin-3-yl)methylamine hydrochloride (1220039-41-7,1432754-64-7,870064-16-7) + 2,3-dichloro-1-isothiocyanatobenzene (6590-97-2) → N-[(2-chloropyridin-3-yl)methyl]-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: trimethylsilylazide; mercury(II) diacetate; triethylamine / tetrahydrofuran / 4 h / 20 °C

With trimethylsilylazide; mercury(II) diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

upstream raw materials:

2-chloro-3-carbaldehydepyridine

Refernces