1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL
• CAS No.: 220247-69-8
• Molecular Formula: C11H13NO2.ClH
• Molecular Weight: 227.69
• Hs Code.: 2933499090
• Mol file: 220247-69-8.mol

Synonyms:METHYL 1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLATE HYDROCHLORIDE;7-METHOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL;1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;Methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate HCL;7-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-, Methyl ester, hydrochloride

Chemical Property of 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL

Chemical Property:

• PSA: 38.33000
• LogP: 2.24970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Methyl1,2,3,4-Tetrahydroisoquinoline-7-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL

There total 2 articles about 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,2,3,4-tetrahydro-isoquinoline-7-carbonitrile hydrochloride → methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride (220247-69-8)

Guidance literature:

With hydrogenchloride; water; In methanol; for 18h; Heating / reflux;

Reference yield:

methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate (220247-50-7) → methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride (220247-69-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b00140

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride (220247-69-8) → 2-tert-butyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate (960305-54-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate

Downstream raw materials:

2-tert-butyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate

2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Refernces

• 1、 -. "COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES". Page/Page column 13; 29. . Retrieved 2010/02/14.