S-(4-fluorophenyl)-S-Methyl-SulfoxiMine

Base Information

• Chemical Name: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine
• CAS No.: 635311-89-6
• Molecular Formula: C7H8FNOS
• Molecular Weight: 173.211
• Hs Code.: 29350090
• Mol file: 635311-89-6.mol

Synonyms:S-(4-fluorophenyl)-S-Methyl-SulfoxiMine

Chemical Property of S-(4-fluorophenyl)-S-Methyl-SulfoxiMine

Chemical Property:

• Melting Point: 93-94 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 233.3±42.0 °C(Predicted)
• PSA: 49.30000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 2.82660

Purity/Quality:

99% ^*data from raw suppliers

S-Methyl-S-(4-fluorophenyl)sulfoximine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-37/38-48
• Safety Statements: 22-26-7/8-36/37/39-45

MSDS Files:

Useful:

Technology Process of S-(4-fluorophenyl)-S-Methyl-SulfoxiMine

There total 2 articles about S-(4-fluorophenyl)-S-Methyl-SulfoxiMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-fluorothioanisole (371-15-3) → (4-fluorophenyl)(imino)(methyl)-λ6-sulfanone (635311-89-6)

Guidance literature:

With [bis(acetoxy)iodo]benzene; ammonium acetate; In ethanol; at 20 ℃; for 2h;

Reference yield: 74.0%

4-fluorophenyl methyl sulfoxide (658-14-0) → (4-fluorophenyl)(imino)(methyl)-λ6-sulfanone (635311-89-6)

Guidance literature:

With sodium azide; In chloroform; at 45 ℃;

DOI:10.1021/jm040129+

Reference yield: 99.0%

4-methoxycarbonylphenyl bromide (619-42-1) + (4-fluorophenyl)(imino)(methyl)-λ6-sulfanone (635311-89-6) → methyl 4-(((4-fluorophenyl)(methyl)(oxo)-λ6-sulfaneylidene)amino)benzoate

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; nickel(II)-4,4'-di(tert-butyl-2,2'-bipyridine) bromide; N,N,N',N'-tetramethylguanidine; In acetonitrile; at 25 ℃; for 17h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b00698

upstream raw materials:

4-fluorophenyl methyl sulfoxide

p-fluorothioanisole

Downstream raw materials:

C₁₃H₂₂FNOSSi

C₄₇H₈₂FNO₃SSi₃

Refernces

• 1、 Li, Jian,Li, Hui,Fang, Daqing,Liu, Lingjun,Han, Xu,Sun, Jina,Li, Chunpu,Zhou, Yu,Ye, Deju,Liu, Hong. "Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines". . p. 15217 - 15227. Retrieved 2021/10/25.
• 2、 Xie, Haisheng,Lan, Jianyong,Gui, Jiao,Chen, Fengjuan,Jiang, Huangfeng,Zeng, Wei. "Ru (II)-Catalyzed Coupling-Cyclization of Sulfoximines with alpha-Carbonyl Sulfoxonium Ylides as an Approach to 1,2-Benzothiazines". . p. 3534 - 3543. Retrieved 2018/08/06.