4-acetamido-3-fluorobenzene-1-sulfonyl chloride

Base Information

• Chemical Name: 4-acetamido-3-fluorobenzene-1-sulfonyl chloride
• CAS No.: 349-71-3
• Molecular Formula: C8H7ClFNO3S
• Molecular Weight: 251.666
• Hs Code.: 2924299090
• Mol file: 349-71-3.mol

Synonyms:4-acetamido-3-fluorobenzene-1-sulfonyl chloride;4-(ACETYLAMINO)-3-FLUOROBENZENESULFONYL CHLORIDE;N-acetyl-2-fluoro-4-chlorosulphonylaniline;4-chlorosulfonyl-2-fluoroacetanilide;3-fluoro-4-acetamidobenzene sulfonylchloride;

Chemical Property of 4-acetamido-3-fluorobenzene-1-sulfonyl chloride

Chemical Property:

• PSA: 75.11000
• LogP: 3.44190

Purity/Quality:

98%min ^*data from raw suppliers

4-Acetamido-3-fluorobenzene-1-sulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-acetamido-3-fluorobenzene-1-sulfonyl chloride

There total 4 articles about 4-acetamido-3-fluorobenzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-fluorophenyl)acetamide (399-31-5) → 3-fluoro-4-acetamidobenzene sulfonylchloride (349-71-3)

Guidance literature:

With chlorosulfonic acid; at 70 ℃; for 3h;

DOI:10.1021/jm021123s

Reference yield:

2-Fluoroaniline (348-54-9) → 3-fluoro-4-acetamidobenzene sulfonylchloride (349-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 0.5 h / Heating

2: chlorosulfonic acid / 3 h / 70 °C

With chlorosulfonic acid;

DOI:10.1021/jm021123s

Reference yield:

N-acetyl-2-fluoro-4-sulphoaniline triethylamine salt (1:1) (244144-49-8) → 3-fluoro-4-acetamidobenzene sulfonylchloride (349-71-3)

Guidance literature:

N-acetyl-2-fluoro-4-sulphoaniline triethylamine salt (1:1); With trichlorophosphate; at 0 - 20 ℃; for 15.5h;

With water; at 0 ℃; for 0.25h;

upstream raw materials:

N-(2-fluorophenyl)acetamide

2-Fluoroaniline

N-acetyl-2-fluoro-4-sulphoaniline triethylamine salt (1:1)

4-amino-3-fluorobenzenesulfonic acid

Downstream raw materials:

N-[2-fluoro-4-(4-methylpiperidin-1-sulfonyl)phenyl]acetamide

N-[2-fluoro-4-(piperidin-1-sulfonyl)phenyl]acetamide

5-(4-amino-3-fluoro-benzenesulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide

4-amino-3-fluorobenzenesulfonamide

Refernces

• 1、 Patel, Pratik R.,Ramalingan, Chennan,Park, Yong-Tae. "Synthesis and antimicrobial evaluation of guanylsulfonamides". . p. 6610 - 6614. Retrieved 2008/09/18.
• 2、 -. "Benzenesulfonamide-derivatives and their use as medicaments". . . Retrieved 2010/11/30.