TrifluoroMethoxyacetic Acid

Base Information

• Chemical Name: TrifluoroMethoxyacetic Acid
• CAS No.: 69105-00-6
• Molecular Formula: C3H3F3O3
• Molecular Weight: 144.05
• Hs Code.: 2918999090
• Mol file: 69105-00-6.mol

Synonyms:Trifluormethansulfonsaeure-;p-Toluenesulfonylmethyl trifluoromathanesulfonate;CF30CH2C(O)OH;2-trifluoromethoxyacetic acid;p-Tolylsulfonylmethyl-trifluormethansulfonat;Methanesulfonic acid,trifluoro-,[(4-methylphenyl)sulfonyl]methyl ester;p-tosylmethyl trifluoromethanesulphonate;Trifluormethoxyessigsaeure;Methanesulfonic acid,[(4-methylphenyl)sulfonyl]methyl ester;

Chemical Property of TrifluoroMethoxyacetic Acid

Chemical Property:

• Boiling Point: 140.8±35.0 °C(Predicted)
• PKA: 2.42±0.10(Predicted)
• PSA: 46.53000
• Density: 1.509±0.06 g/cm3(Predicted)
• LogP: 0.60740

Purity/Quality:

95+% ^*data from raw suppliers

2-(Trifluoromethoxy)acetic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Trifluoromethoxyacetic Acid is used as a reactant in the preparation of perfluoroalkoxyacetic acid derivatives.

Technology Process of TrifluoroMethoxyacetic Acid

There total 2 articles about TrifluoroMethoxyacetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

sodium 2-trifluoromethoxyacetate (1198089-28-9) → 2-(trifluoromethoxy)acetic acid (69105-00-6)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 12h;

Reference yield:

methyl (trifluoromethoxy)acetate (69104-99-0) → 2-(trifluoromethoxy)acetic acid (69105-00-6)

Guidance literature:

With sodium hydroxide;

Reference yield: 81.0%

2-(trifluoromethoxy)acetic acid (69105-00-6) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-2-(trifluoromethoxy)acetamide

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 10 - 20 ℃; for 12h;

DOI:10.1016/j.jfluchem.2020.109461

upstream raw materials:

methyl (trifluoromethoxy)acetate

sodium 2-trifluoromethoxyacetate

Refernces