1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide

Base Information

• Chemical Name: 1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide
• CAS No.: 1338925-11-3
• Molecular Formula: C24H24N2O
• Molecular Weight: 356.467
• Hs Code.: 2933990090
• Mol file: 1338925-11-3.mol

Synonyms:MN-24;

Chemical Property of 1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide

Chemical Property:

• PSA: 34.03000
• Density: 1.12±0.1 g/cm3 (20 oC 760 Torr), Calc.*
• LogP: 6.31000

Purity/Quality:

99%, ^*data from raw suppliers

N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: JWH 018 is a potent synthetic cannabinoid which has been identified in smoking mixtures. NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
• Uses: N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide is a novel indole and azaindole cannabinoid receptor agonists. N-1-Naphthalenyl-1-pentyl-1H-indole-3-carboxamide is a novel indole and azaindole cannabinoid receptor agonists. Synthetic Cannabinoids

Technology Process of 1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide

There total 3 articles about 1-pentyl-N-(naphthalen-1-yl)-1H-indole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 1-pentyl-1H-indole-3-carboxylate (1338925-20-4) + 1-amino-naphthalene (134-32-7) → N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide (1338925-11-3)

Guidance literature:

1-amino-naphthalene; With trimethylaluminum; In 1,2-dichloro-ethane; toluene; at 20 ℃; for 0.166667h; Inert atmosphere;

methyl 1-pentyl-1H-indole-3-carboxylate; In 1,1,1-trichloroethane; toluene; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2011.08.021

Reference yield:

3-methoxycarbonylindole (942-24-5) → N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide (1338925-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

With trimethylaluminum; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.ejmech.2011.08.021

Reference yield:

1-Bromopentane (110-53-2) → N-(naphthalen-1-yl)-1-pentyl-1H-indole-3-carboxamide (1338925-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere; Reflux

With trimethylaluminum; sodium hydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1016/j.ejmech.2011.08.021

upstream raw materials:

methyl 1-pentyl-1H-indole-3-carboxylate

1-amino-naphthalene

3-methoxycarbonylindole

1-Bromopentane

Refernces