5-Ethyl-5-methylhydantoin

Base Information

• Chemical Name: 5-Ethyl-5-methylhydantoin
• CAS No.: 16820-12-5
• Molecular Formula: C6H10N2O2
• Molecular Weight: 142.15600
• Mol file: 16820-12-5.mol

Synonyms:MEH;5-ethyl-5-methyl-4-imidazolidinedione;5-Ethyl-5-methyl-2,4-imidazolidinedione;5-ethyl-5-methyl-hydantoi;5-methyl-5-ethylhydantoin;

Chemical Property of 5-Ethyl-5-methylhydantoin

Chemical Property:

• Melting Point: 144-150oC
• Refractive Index: 1.5010 (estimate)
• Boiling Point: 259.72°C (rough estimate)
• PSA: 58.20000
• Density: 1.095g/cm3
• LogP: 0.65210

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Ethyl-5-methylhydantoin

There total 18 articles about 5-Ethyl-5-methylhydantoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ (5S)-5-ethyl-5-methylimidazolidine-2,4-dione (16820-13-6,16820-12-5)

Guidance literature:

In water; at 90 ℃; for 2h;

With hydrogenchloride; In water; at 90 ℃; for 1h;

Reference yield: 91.283%

tert-butyl N-[(1R)-1-carbamoyl-1-methyl-propyl]carbamate → (5R)-5-ethyl-5-methylimidazolidine-2,4-dione (16820-12-5)

Guidance literature:

With potassium carbonate; In butan-1-ol; at 95 ℃; Inert atmosphere;

Reference yield: 91.0%

potassium cyanate (590-28-3) + (2R)-2-amino-2-methylbutanoic acid (3059-97-0,465-58-7) → (5R)-5-ethyl-5-methylimidazolidine-2,4-dione (16820-12-5)

Guidance literature:

potassium cyanate; (2R)-2-amino-2-methylbutanoic acid; In water; at 90 ℃; for 3h;

With hydrogenchloride; In water; at 90 ℃; for 2h;

upstream raw materials:

2-amino-2-methylbutanenitrile

2-hydroxy-2-methyl-butyronitrile

hydrogen cyanide

butanone

Refernces

• 1、 -. "KV3 MODULATORS". Page/Page column 55-56. . Retrieved 2021/08/14.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 54-55. . Retrieved 2020/05/21.