2-Methyl-5-nitroimidazole

Base Information

• Chemical Name: 2-Methyl-5-nitroimidazole
• CAS No.: 88054-22-2
• Molecular Formula: C4H5N3O2
• Molecular Weight: 127.10100
• Hs Code.: 2933290090
• Mol file: 88054-22-2.mol

Synonyms:

Chemical Property of 2-Methyl-5-nitroimidazole

Chemical Property:

• Melting Point: 252-254oC
• Refractive Index: 1.5000 (estimate)
• Boiling Point: 0oC
• Flash Point: 0oC
• PSA: 74.50000
• Density: 1.426
• LogP: 1.14950
• Storage Temp.: Refrigerator
• Solubility.: Slightly soluble in ethanol, easily soluble in diluted acid and

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-5-nitroimidazole ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl-4(5)-nitroimidazole was used to study the mechanism of both the alkaline and acidic hydrolysis of tinidazole. It is mainly used to synthesize intermediate of medicines such as Metronidazole and dimetridazole. 2-Methyl-5-nitroimidazole (Tinidazole EP Impurity A) is a Floconazole impurity.

Technology Process of 2-Methyl-5-nitroimidazole

There total 10 articles about 2-Methyl-5-nitroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

2-methylimidazole (693-98-1) → 2-methyl-5-nitro-1H-imidazole (696-23-1,88054-22-2)

Guidance literature:

With hydrogenchloride; sodium nitrate; nitric acid; at 70 - 120 ℃;

Reference yield:

4-iodo-2-methyl-5-nitro-1H-imidazole (13369-83-0) → 2-methyl-5-nitro-1H-imidazole (696-23-1,88054-22-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 0.333333h; under 50 Torr; Pressure;

Reference yield:

4-bromo-2-methyl-5-nitroimidazole (18874-52-7) → 2-methyl-5-nitro-1H-imidazole (696-23-1,88054-22-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 0.5h; under 100 Torr; Pressure;

upstream raw materials:

2-methylimidazole

metronidazole

4-iodo-2-methyl-5-nitro-1H-imidazole

4-bromo-2-methyl-5-nitroimidazole

Downstream raw materials:

2?methyl?5?nitro?1?(prop?2?yn?1?yl)?1H?imidazole

(R)-1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol

2-methyl-4-nitro-1-(2-phenoxyethyl)-1H-imidazole

2-methyl-4-nitro-1-phenethyl-1H-imidazole

Refernces

• 1、 Bajkacz, Sylwia,Felis, Ewa,Kasprzyk, Patrycja,Stando, Klaudia. "Heterogeneous photocatalysis of metronidazole in aquatic samples". supporting information. . Retrieved 2021/12/24.
• 2、 -. "Novel nitroimidazole drug as well as preparation method and application of novel nitroimidazole drug". Paragraph 0022. . Retrieved 2018/04/01.