Methyl 3-aMino-2-phenylpropanoate hydrochloride

Base Information

• Chemical Name: Methyl 3-aMino-2-phenylpropanoate hydrochloride
• CAS No.: 91012-17-8
• Molecular Formula: C10H13NO2.ClH
• Molecular Weight: 215.68
• Hs Code.: 2922499990
• Mol file: 91012-17-8.mol

Synonyms:

Chemical Property of Methyl 3-aMino-2-phenylpropanoate hydrochloride

Chemical Property:

• PSA: 52.32000
• LogP: 2.40420

Purity/Quality:

98.5% ^*data from raw suppliers

Methyla-(Aminomethyl)benzeneacetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-aMino-2-phenylpropanoate hydrochloride

There total 8 articles about Methyl 3-aMino-2-phenylpropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 3-amino-2-phenyl-propionic acid (4370-95-0,1008-63-5) → (+/-)-methyl 3-amino-2-phenylpropanoate hydrochloride (91012-17-8)

Guidance literature:

With oxalyl dichloride; at 20 ℃; for 120h;

Reference yield: 85.1%

methyl 2-cyano-2-phenylacetate (30698-30-7) → (+/-)-methyl 3-amino-2-phenylpropanoate hydrochloride (91012-17-8)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; chloroform; at 18 ℃; for 18h; under 1900 Torr;

Reference yield: 57.0%

methanol (67-56-1) + 3-amino-2-phenyl-propionic acid hydrochloride (90765-41-6,1392090-21-9) → (+/-)-methyl 3-amino-2-phenylpropanoate hydrochloride (91012-17-8)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃;

3-amino-2-phenyl-propionic acid hydrochloride; for 3h; Reflux;

upstream raw materials:

methyl 2-cyano-2-phenylacetate

α-phenylcyanoacetic acid

phenylacetonitrile

benzyl 3-(1,3-dioxoisoindolin-2-yl)-2-phenylpropanoate

Downstream raw materials:

methyl 3-(diphenylmethyleneamino)-2-phenylpropanoate

3-amino-2-phenyl-propionic acid

Refernces

• 1、 -. "FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY". . . Retrieved 2019/03/17.
• 2、 Cox, Russell J.,O'Hagan, David. "Synthesis of Isotopically Labelled 3-Amino-2-phenylpropionic Acid and Its Role as a Precursor in the Biosynthesis of Tenellin and Tropic Acid". . p. 2537 - 2540. Retrieved 2007/10/02.