2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)-

Base Information

• Chemical Name: 2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)-
• CAS No.: 916313-75-2
• Molecular Formula: C13H15NO
• Molecular Weight: 201.26400
• Mol file: 916313-75-2.mol

Synonyms:2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)-;

Chemical Property of 2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)-

Chemical Property:

• Melting Point: 102-103 °C
• Boiling Point: 364.6±27.0 °C (760 mmHg)
• PSA: 32.86000
• Density: 1.111±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.99790

Purity/Quality:

98% ^*data from raw suppliers

2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)-

There total 11 articles about 2-BUTANONE,4-(7-METHYL-1H-INDOL-3-YL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-methyl-1H-indole (933-67-5,261352-51-6) + 2-hydroxy-3-butene (598-32-3) → 4-(7-methyl-1H-indol-3-yl)butan-2-one (916313-75-2)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; lithium acetate dihydrate; silver(I) acetate; copper(II) acetate monohydrate; In 1,2-dichloro-ethane; at 130 ℃; for 48h; Inert atmosphere;

DOI:10.1002/chem.201706080

Reference yield: 85.0%

7-methyl-1H-indole (933-67-5,261352-51-6) + methyl vinyl ketone (78-94-4,25038-87-3) → 4-(7-methyl-1H-indol-3-yl)butan-2-one (916313-75-2)

Guidance literature:

With gallium(III) iodide; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2006.08.108

Reference yield: 85.0%

(±)-allyl 7-methyl-3-(3-oxobutyl)-3H-indole-3-carboxylate → 4-(7-methyl-1H-indol-3-yl)butan-2-one (916313-75-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; acetic acid; In dichloromethane; at 23 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201300515

upstream raw materials:

7-methyl-1H-indole

methyl vinyl ketone

1-methyl-2-nitrobenzene

(E)-α-ethenyl-α-methyl-N-(2-methylphenyl)nitrone

Refernces

• 1、 San, Htet Htet,Huang, Jie,Lei Aye, Seinn,Tang, Xiang-Ying. "Boron-Catalyzed Dehydrative Friedel-Crafts Alkylation of Arenes Using β-Hydroxyl Ketone as MVK Precursor". supporting information. p. 2386 - 2391. Retrieved 2021/01/04.
• 2、 Xia, Ying-Qi,Li, Chao,Liu, Man,Dong, Lin. "Ruthenium-Catalyzed Selective C?C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst". supporting information. p. 5474 - 5478. Retrieved 2018/03/29.