4-bromo-N-pyridin-2-ylbenzamide

Base Information

• Chemical Name: 4-bromo-N-pyridin-2-ylbenzamide
• CAS No.: 14547-83-2
• Molecular Formula: C12H9BrN2O
• Molecular Weight: 277.12
• Hs Code.: 2933399090
• Mol file: 14547-83-2.mol

Synonyms:BENZAMIDE,4-BROMO-N-2-PYRIDINYL-;

Chemical Property of 4-bromo-N-pyridin-2-ylbenzamide

Chemical Property:

• PSA: 41.99000
• LogP: 3.16940

Purity/Quality:

99% ^*data from raw suppliers

4-bromo-N-pyridin-2-ylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-N-pyridin-2-ylbenzamide

There total 31 articles about 4-bromo-N-pyridin-2-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-aminopyridine (504-29-0) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 4-bromo-N-(pyridin-2-yl)benzamide (14547-83-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In toluene; at 100 ℃; for 2h;

DOI:10.1039/c9ra06724h

Reference yield: 87.0%

2-aminopyridine (504-29-0) + 1-(4-bromophenyl)ethanol (5391-88-8) → 4-bromo-N-(pyridin-2-yl)benzamide (14547-83-2)

Guidance literature:

With tert.-butylhydroperoxide; trifluorormethanesulfonic acid; tetra-(n-butyl)ammonium iodide; In water; at 80 ℃; Sealed tube;

DOI:10.1021/acs.joc.8b01956

Reference yield: 86.0%

2-aminopyridine (504-29-0) + 4-Bromobenzoic acid (586-76-5) → 4-bromo-N-(pyridin-2-yl)benzamide (14547-83-2)

Guidance literature:

4-Bromobenzoic acid; With oxalyl dichloride; In dichloromethane; for 1h; Reflux;

2-aminopyridine; With pyridine; In dichloromethane; at 5 ℃; for 1h;

upstream raw materials:

N-(4-bromobenzylidene)pyridin-2-amine

2-aminopyridine

4-bromo-benzaldehyde

2-aminopyridine N-oxide

Downstream raw materials:

(S)-2-((1-(4-(pyridin-2-ylcarbamoyl)phenyl)-8-amino)imidazole[1,5-a]pyrazin-2-yl)pyrrolidine1-yl-carboxylic acid benzyl ester

benzyl (3R)-3-(8-amino-1-(4-[(pyridin-2-yl)carbamoyl]phenyl)imidazo[1,5-a]pyrazin-3-yl)piperidine-1-carboxylate

Refernces

• 1、 Ma, Haojie,Lu, Guoqiang,Han, Bo,Huang, Guosheng,Zhang, Yuqi,Wang, Ji-Jiang. "Copper(I)-catalysed aerobic oxidative selective cleavage of C[sbnd]C bond with DMAP: Facile access to N-substituted benzamides". supporting information. . Retrieved 2021/06/15.
• 2、 Cheruku, Srinivas,Sajith, Ayyiliath M.,Narayana, Yatheesh,Shetty, Poornima,Nagarakere, Sandhya C.,Sagar, Kunigal S,Manikyanally, Kumara N.,Rangappa, Kanchugarkoppal Subbegowda,Mantelingu, Kempegowda. "Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines". . p. 5530 - 5537. Retrieved 2021/05/07.