N-Methyltyramine

Base Information

• Chemical Name: N-Methyltyramine
• CAS No.: 370-98-9
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• European Community (EC) Number: 206-731-3
• NSC Number: 113958
• UNII: G3S4E2F7TA
• DSSTox Substance ID: DTXSID60190496
• Nikkaji Number: J50.151D
• Wikipedia: N-Methyltyramine
• Wikidata: Q309527
• Metabolomics Workbench ID: 38377
• Mol file: 370-98-9.mol

Synonyms:methyl-4-tyramine;methyl-4-tyramine hydrobromide;methyl-4-tyramine hydrochloride;N-methyltyramine;N-methyltyrosamine

Chemical Property of N-Methyltyramine

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Melting Point: 130～131℃
• Boiling Point: 270.9 °C at 760 mmHg
• PKA: 9.86±0.15(Predicted)
• Flash Point: 119.7 °C
• PSA: 32.26000
• Density: 1.036 g/cm³
• LogP: 1.54500
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

99% ^*data from raw suppliers

N-Methyl-p-tyramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: CNCCC1=CC=C(C=C1)O

Technology Process of N-Methyltyramine

There total 24 articles about N-Methyltyramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(2-bromoethyl)phenol (14140-15-9) + methylamine (74-89-5) → N-methyltyramine (370-98-9)

Guidance literature:

In methanol; at 20 ℃;

Reference yield: 36.0%

4-methoxyphenethyl bromide (14425-64-0) + methylamine (74-89-5) → N-methyltyramine (370-98-9)

Guidance literature:

4-methoxyphenethyl bromide; methylamine; In ethanol; at 20 ℃; for 18h;

With water; boron tribromide; In hexane; dichloromethane; for 0.666667h;

Reference yield:

methanol (67-56-1) + tyrosamine (51-67-2) → N,N-dimethyltyramine (539-15-1) + N-methyltyramine (370-98-9)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen; potassium carbonate; at 120 ℃; for 24h; under 30003 Torr; Glovebox;

DOI:10.1002/anie.201801524

upstream raw materials:

N-methylhomoanisylamine

N-methyl-L-tyrosine

N-methyltyrosine

N-(4-hydroxyphenethyl)-N-methylacetamide

Downstream raw materials:

4-(2-methylamino-ethyl)-2-nitro-phenol

2-bromo-4-methoxy-5-hydroxy-N-[2-(4-hydroxyphenyl)-ethyl]-N-methylbenzamide

N-tert-butoxycarbonyl-N-methyl-2-(4-hydroxyphenyl)-ethylamine

N-Methyltyramine hydrochloride

Refernces

• 1、 Choi, Geunho,Hong, Soon Hyeok. "Selective Monomethylation of Amines with Methanol as the C1 Source". supporting information. p. 6166 - 6170. Retrieved 2018/04/30.
• 2、 -. "COMPOUNDS". Page/Page column 13-14. . Retrieved 2009/09/08.