4,5-DIBROMO-1,2-DIMETHYL-1H-IMIDAZOLE

Base Information

• Chemical Name: 4,5-DIBROMO-1,2-DIMETHYL-1H-IMIDAZOLE
• CAS No.: 16954-05-5
• Molecular Formula: C5H6Br2N2
• Molecular Weight: 253.924
• Hs Code.: 2933290090
• Mol file: 16954-05-5.mol

Synonyms:Imidazole,4,5-dibromo-1,2-dimethyl- (8CI);4,5-Dibromo-1,2-dimethylimidazole;NSC 191261;

Chemical Property of 4,5-DIBROMO-1,2-DIMETHYL-1H-IMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.000302mmHg at 25°C
• Melting Point: 77-78 °C
• Refractive Index: 1.647
• Boiling Point: 331.3 °C at 760 mmHg
• PKA: 3.13±0.60(Predicted)
• Flash Point: 154.2 °C
• PSA: 17.82000
• Density: 2.06 g/cm³
• LogP: 2.25350
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4,5-Dibromo-1,2-dimethyl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,5-DIBROMO-1,2-DIMETHYL-1H-IMIDAZOLE

There total 3 articles about 4,5-DIBROMO-1,2-DIMETHYL-1H-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4,5-Dibromo-2-methylimidazole (4002-81-7) + dimethyl sulfate (77-78-1) → 4,5-dibromo-2-methyl-1-methylimidazole (16954-05-5)

Guidance literature:

With sodium hydroxide; In water; at 40 ℃;

DOI:10.1016/j.bmcl.2013.01.004

Reference yield: 81.0%

1,2-dimethyl-1H-imidazole (1739-84-0) → 4,5-dibromo-2-methyl-1-methylimidazole (16954-05-5)

Guidance literature:

With N-Bromosuccinimide; In chloroform; at 20 ℃;

DOI:10.1016/j.ejmech.2018.10.049

Reference yield:

(1,2-dimethyl-1H-imidazol-5-yl)methanol (24021-93-0) → 5-bromo-1,2-dimethyl-1H-imidazole (24134-09-6) + 4,5-dibromo-2-methyl-1-methylimidazole (16954-05-5)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; potassium bromide; In dichloromethane; at 0 ℃; for 6h;

DOI:10.1021/op9002505

upstream raw materials:

1,2-dimethyl-1H-imidazole

4,5-Dibromo-2-methylimidazole

dimethyl sulfate

(1,2-dimethyl-1H-imidazol-5-yl)methanol

Refernces

• 1、 de Gaetano, Monica,Butler, Eibhlín,Gahan, Kevin,Zanetti, Andrea,Marai, Mariam,Chen, Jianmin,Cacace, Antonino,Hams, Emily,Maingot, Catherine,McLoughlin, Alisha,Brennan, Eoin,Leroy, Xavier,Loscher, Christine E.,Fallon, Padraic,Perretti, Mauro,Godson, Catherine,Guiry, Patrick J.. "Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)". . p. 80 - 108. Retrieved 2018/11/21.
• 2、 -. "HETEROCYCLIC LIPXON ANALOGS AND USES THEROF". Page/Page column 74. . Retrieved 2018/03/09.