4-Piperidinecarboxylicacid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-

Base Information

• Chemical Name: 4-Piperidinecarboxylicacid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-
• CAS No.: 956460-96-1
• Molecular Formula: C17H23N5O4
• Molecular Weight: 361.401
• Hs Code.: 2933990090
• Mol file: 956460-96-1.mol

Synonyms:4-[(tert-Butoxycarbonyl)amino]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid;

Chemical Property of 4-Piperidinecarboxylicacid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-

Chemical Property:

• PSA: 120.44000
• Density: 1.37±0.1 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.36210

Purity/Quality:

99.3% ^*data from raw suppliers

4-[(tert-Butoxycarbonyl)amino]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinecarboxylicacid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-

There total 9 articles about 4-Piperidinecarboxylicacid,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester (956460-97-2) → 4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (956460-96-1)

Guidance literature:

4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 60 ℃; for 18h;

With hydrogenchloride; water; at 0 ℃; pH=4 - 5;

Reference yield: 63.0%

4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid (252720-31-3) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → 4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (956460-96-1)

Guidance literature:

4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With sodium hydrogencarbonate; In water; acetonitrile; for 24h; Heating / reflux;

With hydrogenchloride; water; pH=4.5;

Reference yield:

C17H22ClN5O4 → 4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (956460-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; triethylamine; In ethanol;

upstream raw materials:

4-tert-butoxycarbonylamino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-piperidine-4-carboxylic acid ethyl ester

4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

Downstream raw materials:

tert-butyl 4-(1-(4-chlorophenyl)-2-hydroxyethylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

(R)-methyl 3-(4-(tert-butoxycarbonylamino)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)-3-(4-chlorophenyl)propanoate

tert-butyl 4-(((4-chlorophenyl)cyano)methylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

tert-butyl 4-(1-(4-chlorophenyl)-3-(dimethylamino)propylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Refernces

• 1、 Addie, Matt,Ballard, Peter,Buttar, David,Crafter, Claire,Currie, Gordon,Davies, Barry R.,Debreczeni, Judit,Dry, Hannah,Dudley, Philippa,Greenwood, Ryan,Johnson, Paul D.,Kettle, Jason G.,Lane, Clare,Lamont, Gillian,Leach, Andrew,Luke, Richard W. A.,Morris, Jeff,Ogilvie, Donald,Page, Ken,Pass, Martin,Pearson, Stuart,Ruston, Linette. "Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases". . p. 2059 - 2073. Retrieved 2013/05/08.
• 2、 -. "SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY". Page/Page column 109. . Retrieved 2008/12/06.