N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt

Base Information

• Chemical Name: N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt
• CAS No.: 51583-51-8
• Molecular Formula: C₅H₁₂ClNO
• Molecular Weight: 137.609
• Hs Code.: 2922199090
• Mol file: 51583-51-8.mol

Synonyms:3-Chloro(2-hydroxypropyl)dimethylamine;NSC 11747

Chemical Property of N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt

Chemical Property:

• Vapor Pressure: 0.0984mmHg at 25°C
• Boiling Point: 197.1°Cat760mmHg
• Flash Point: 73°C
• PSA: 23.47000
• Density: 1.078g/cm³
• LogP: 0.14770

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-3-(dimethylamino)-propan-2-ol hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt

There total 2 articles about N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl amine (124-40-3) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → (+/-)-1-chloro-3-(diethylamino)-2-propanol (51583-51-8)

Guidance literature:

In ethanol; at -5 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

diethylamine (109-89-7) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → (+/-)-1-chloro-3-(diethylamino)-2-propanol (51583-51-8)

Guidance literature:

DOI:10.1016/j.bmcl.2004.06.051

Reference yield:

(+/-)-1-chloro-3-(diethylamino)-2-propanol (51583-51-8) + 4-(5-chloro-2-hydroxy-phenyl)-3-mercapto-6-trifluoromethyl-1H-quinolin-2-one (761442-96-0) → 4-(5-chloro-2-hydroxy-phenyl)-3-(3-dimethylamino-2-hydroxy-propylsulfanyl)-6-trifluoromethyl-1H-quinolin-2-one

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 23 ℃; for 16h;

DOI:10.1016/j.bmcl.2004.06.051

upstream raw materials:

diethylamine

epichlorohydrin

dimethyl amine

Refernces

• 1、 Hewawasam, Piyasena,Fan, Wenhong,Cook, Deborah A.,Newberry, Kimberly S.,Boissard, Christopher G.,Gribkoff, Valentin K.,Starrett, John,Lodge, Nicholas J.. "4-Aryl-3-(mercapto)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle". . p. 4479 - 4482. Retrieved 2007/10/03.