Ticarcillin

Base Information

• Chemical Name: Ticarcillin
• CAS No.: 34787-01-4
• Molecular Formula: C₁₅H₁₆N₂O₆S₂
• Molecular Weight: 384.434
• European Community (EC) Number: 252-213-5
• UNII: F93UJX4SWT
• DSSTox Substance ID: DTXSID0023668
• Nikkaji Number: J17.850K
• Wikipedia: Ticarcillin
• Wikidata: Q2601832
• NCI Thesaurus Code: C889
• Metabolomics Workbench ID: 43593
• ChEMBL ID: CHEMBL1449
• Mol file: 34787-01-4.mol

Synonyms:BRL 2288;BRL-2288;BRL2288;Disodium, Ticarcillin;Tarcil;Ticar;Ticarcillin;Ticarcillin Disodium;Ticarpen;Ticillin

Chemical Property of Ticarcillin

Chemical Property:

• Vapor Pressure: 7.97E-25mmHg at 25°C
• Refractive Index: 1.693
• Boiling Point: 768.3 °C at 760 mmHg
• PKA: pKa 2.89±0.05(H2O t=25.0 I=0.15 (KCl)) (Uncertain);3.28±0.04 (Uncertain)
• Flash Point: 418.4 °C
• PSA: 177.55000
• Density: 1.62 g/cm³
• LogP: 0.87680
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 384.04497858
• Heavy Atom Count: 25
• Complexity: 640

Purity/Quality:

99% ^*data from raw suppliers

Ticarcillin Supplement formicrobiology ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Antiinfective Agents
• Canonical SMILES: CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CSC=C3)C(=O)O)C(=O)O)C
• Isomeric SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CSC=C3)C(=O)O)C(=O)O)C
• Description: Temocillin disodium is a broad-spectrum, β-lactamase resistant, injectable penicillin. High serum levels and a five hour half-life allow once or twice-daily dosing.
• Uses: Ticarcillin (SB) is a significant penicillin antibiotic that incorporates the thiophene ring system. Ticarcillin is a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa. Ticarcillin is a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, part icularly Pseudomonas aeruginosa.
• Clinical Use: Serious infection, including septicemia, respiratory tract infections, genitourinary tract infections and skin and soft-tissue infections caused by susceptible bacteria

Technology Process of Ticarcillin

There total 3 articles about Ticarcillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

monosodium ticarcillin + sodium 2-ethylhexanoic acid → ticarcillin (3973-04-4,34787-01-4,94493-53-5)

Guidance literature:

In ethanol; water;

Reference yield: 67.7%

→ ticarcillin (3973-04-4,34787-01-4,94493-53-5)

Guidance literature:

Reference yield:

→ (S)-6-(2-Carboxy-2-thiophen-3-yl-acetylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (3973-04-4,34787-01-4,94493-53-5)

Guidance literature:

aus 6-Amino-penicillansaeure, Bis-trimethylsilylacetamid, 2,2-Dimethyl-5-(3-thienyl)-1,3-dioxan-4,6-dion;

Refernces

• 1、 -. "Enhancement of the efficacy of nifedipine by deuteration". . . Retrieved 2008/06/13.
• 2、 -. "β-lactam antibiotics". . . Retrieved 2008/06/13.