2-Methoxy-6-methylphenol

Base Information

• Chemical Name: 2-Methoxy-6-methylphenol
• CAS No.: 2896-67-5
• Molecular Formula: C8H10 O2
• Molecular Weight: 138.166
• Hs Code.: 2909500000
• European Community (EC) Number: 608-297-4
• NSC Number: 7374
• UNII: BV9KQQ59VO
• DSSTox Substance ID: DTXSID20183167
• Nikkaji Number: J141.495J
• Wikidata: Q27274909
• Mol file: 2896-67-5.mol

Synonyms:2-Methoxy-6-methylphenol;2896-67-5;2-Hydroxy-3-methoxytoluene;Phenol, 2-methoxy-6-methyl-;6-Methylguaiacol;2-Hydroxy-3-methylanisole;UNII-BV9KQQ59VO;BV9KQQ59VO;2-methoxy-6-methyl-phenol;NSC 7374;NSC-7374;MFCD00043771;6-methoxy-2-methylphenol;o-Creosol;Resins, Paper;2-hydroxy-3-methoxy-toluene;SCHEMBL50085;ghl.PD_Mitscher_leg0.672;DTXSID20183167;NSC7374;AKOS006230634;PS-4138;BP-10123;SY101524;CS-0153682;FT-0612535;EN300-202686;A919050;Q27274909;86729-25-1

Chemical Property of 2-Methoxy-6-methylphenol

Chemical Property:

• Vapor Pressure: 0.0758mmHg at 25°C
• Boiling Point: 220.6°Cat760mmHg
• Flash Point: 91.6°C
• PSA: 29.46000
• Density: 1.078g/cm³
• LogP: 1.70920
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 138.068079557
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

99.5% ^*data from raw suppliers

2-Methoxy-6-methylphenol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: UVCB
• Canonical SMILES: CC1=C(C(=CC=C1)OC)O

Technology Process of 2-Methoxy-6-methylphenol

There total 36 articles about 2-Methoxy-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-methyl-6-methoxyphenol (2896-67-5)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; for 72h;

DOI:10.1021/ja00156a005

Reference yield: 84.0%

2-hydroxy-3-methoxybenzyl alcohol (4383-05-5) → 2-methyl-6-methoxyphenol (2896-67-5)

Guidance literature:

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In acetic acid; at 100 ℃; for 7h; under 3040 Torr;

DOI:10.1021/jm00161a029

Reference yield: 80.0%

1-methoxy-3-methyl-benzene (100-84-5) → 2-Methoxy-4-methylphenol (93-51-6) + 1-hydroxy-4-methoxy-2-methylbenzene (5307-05-1) + 2-methyl-6-methoxyphenol (2896-67-5)

Guidance literature:

With wild type cytochrome P₄₅₀ CYP₁₀₂A₁ variants RLYF/A₃₃₀P; oxygen; NADPH; Reagent/catalyst; Enzymatic reaction;

DOI:10.1002/cctc.201700116

upstream raw materials:

3-methoxy-2-hydroxybenzaldehyde

2-hydroxy-3-methoxybenzyl alcohol

1,2-dimethoxy-3-methylbenzene

5-bromo-3-methoxysalicylaldehyde

Downstream raw materials:

6-methylallylguaiacol

1-(2-methoxy-6-methyl-phenoxy)-2,2,3r,4,4-pentamethyl-phosphetane 1c-oxide

1,2-dihydroxy-3-methyl-anthraquinone

4,N-dihydroxy-3-methoxy-5-methylbenzamidine

Refernces

• 1、 Liu, Jie,Ma, Xuebing,Wang, Xuri,Xie, Guangxin,Yin, Zuyong,Zhang, Jianing. "Hollow, mesoporous, eutectic Zn1?xMgxO nano-spheres as solid acid-base catalysts for the highly regio-selectiveO-methylation of 1,2-diphenols". . p. 7454 - 7466. Retrieved 2021/11/23.
• 2、 Chen, Jie-Sheng,Li, Xin-Hao,Su, Juan,Wang, Hong-Hui,Zhang, Jun-Jun,Zhao, Tian-Jian. "Biomimetic Design of a 3 D Transition Metal/Carbon Dyad for the One-Step Hydrodeoxygenation of Vanillin". . . Retrieved 2020/03/30.