4-Hydroxymethyl-1H-indazole

Base Information

• Chemical Name: 4-Hydroxymethyl-1H-indazole
• CAS No.: 709608-85-5
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16200
• Hs Code.: 2933990090
• Mol file: 709608-85-5.mol

Synonyms:1H-indazol-4-ylmethanol;

Chemical Property of 4-Hydroxymethyl-1H-indazole

Chemical Property:

• Vapor Pressure: 1.84E-06mmHg at 25°C
• Boiling Point: 380.3oC at 760 mmHg
• PKA: 13.92±0.40(Predicted)
• Flash Point: 183.8oC
• PSA: 48.91000
• Density: 1.36g/cm3
• LogP: 1.05520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

1H-Indazole-4-methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxymethyl-1H-indazole

There total 1 articles about 4-Hydroxymethyl-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1H-indazole-4-carboxylic acid methyl ester (192945-49-6) → 4-(hydroxymethyl)-1H-indazole (709608-85-5)

Guidance literature:

1H-indazole-4-carboxylic acid methyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃;

With water; Rochelle's salt; In tetrahydrofuran; at 20 ℃;

Reference yield: 70.0%

4-(hydroxymethyl)-1H-indazole (709608-85-5) → 1H-indazole-4-carbaldehyde (669050-70-8)

Guidance literature:

4-(hydroxymethyl)-1H-indazole; With Dess-Martin periodane; In tetrahydrofuran; at 20 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 48.0%

4-(hydroxymethyl)-1H-indazole (709608-85-5) → 4-(bromomethyl)-1H-indazole hydrobromide (264276-18-8)

Guidance literature:

With hydrogen bromide; In water; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00796

upstream raw materials:

1H-indazole-4-carboxylic acid methyl ester

Downstream raw materials:

1H-indazole-4-carbaldehyde

4-(bromomethyl)-1H-indazole hydrobromide

Refernces