Metomidate

Base Information

• Chemical Name: Metomidate
• CAS No.: 5377-20-8
• Deprecated CAS: 11137-51-2,12772-91-7,112366-64-0
• Molecular Formula: C13H14 N2 O2
• Molecular Weight: 230.266
• Hs Code.: 2933290090
• European Community (EC) Number: 226-368-4
• UNII: Z18ZYL8Y51
• DSSTox Substance ID: DTXSID1048411
• Nikkaji Number: J7.978B
• Wikipedia: Metomidate
• Wikidata: Q6824219
• NCI Thesaurus Code: C90941
• ChEMBL ID: CHEMBL494039
• Mol file: 5377-20-8.mol

Synonyms:11C-metomidate;Hypnodil;methoximol;methoxymol;metomidate;R 7315;R-7315

Chemical Property of Metomidate

Chemical Property:

• Vapor Pressure: 5.88E-06mmHg at 25°C
• Refractive Index: 1.6450 (estimate)
• Boiling Point: 379.4°Cat760mmHg
• PKA: 4.15±0.23(Predicted)
• Flash Point: 183.2°C
• PSA: 44.12000
• Density: 1.13g/cm³
• LogP: 2.27900
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.105527694
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

99.9% ^*data from raw suppliers

Metomidate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)N2C=NC=C2C(=O)OC
• Uses: Metomidate is a the methyl ester analogue of Etomidate (E933300), with sedative and hypnotic properties. Metomidate is mainly used as an anesthetic for veterinary use on its own or in combination with Azaperone (A802200) and other sedatives.

Technology Process of Metomidate

There total 1 articles about Metomidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Metomidate (5377-20-8)

Guidance literature:

DL-2-Mercapto-1-<1-phenyl-aethyl>-imidazol-5-carbonsaeure-methylester, wss.HNO3, wss.NaNO2;

DOI:10.1021/jm00326a017

Reference yield:

Metomidate (5377-20-8) + Petroleum ether → (+/-)-1-(1-phenylethyl)-1 H-imidazole-5-carboxylic acid hydrazide (118260-44-9)

Guidance literature:

With hydrazine hydrate; In ethanol; isopropyl alcohol; benzene;

Downstream raw materials:

(+/-)-1-(1-phenylethyl)-1 H-imidazole-5-carboxylic acid hydrazide