GSK1838705A

Base Information

• Chemical Name: GSK1838705A
• CAS No.: 1116235-97-2
• Molecular Formula: C27H29FN8O3
• Molecular Weight: 532.577
• Mol file: 1116235-97-2.mol

Synonyms:2-((2-((1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-6-fluoro-N-methylbenzamide;

Chemical Property of GSK1838705A

Chemical Property:

• PKA: 13.27±0.50(Predicted)
• PSA: 137.46000
• Density: 1.399
• LogP: 2.88670
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble20mg/mL, clear

Purity/Quality:

99% ^*data from raw suppliers

GSK 1838705 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GSK 1838705 is a potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK).

Technology Process of GSK1838705A

There total 1 articles about GSK1838705A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-({2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-fluoro-N-methylbenzamide (1116236-02-2) → GS(387)K1805A (1116235-97-2)

Guidance literature:

With potassium hydroxide; water; In 1,4-dioxane; at 85 - 90 ℃; for 2 - 3h; Product distribution / selectivity;

Reference yield: 80.0%

GS(387)K1805A (1116235-97-2) → C26H27FN8O3

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 50 ℃; for 12h;

DOI:10.1016/j.bmcl.2017.04.085

upstream raw materials:

2-({2-{[1-(N,N-dimethylglycyl)-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino}-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)-6-fluoro-N-methylbenzamide

Refernces