Methyl5-fluoro-6-methylpicolinate

Base Information

• Chemical Name: Methyl5-fluoro-6-methylpicolinate
• CAS No.: 1245647-61-3
• Molecular Formula: C8H8FNO2
• Molecular Weight: 169.15300
• Mol file: 1245647-61-3.mol

Synonyms:methyl 5-fluoro-6-methylpyridine-2-carboxylate

Chemical Property of Methyl5-fluoro-6-methylpicolinate

Chemical Property:

• Boiling Point: 232.2±35.0 °C(Predicted)
• PKA: -0.49±0.10(Predicted)
• PSA: 39.19000
• Density: 1.199±0.06 g/cm3(Predicted)
• LogP: 1.31570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl5-Fluoro-6-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl5-fluoro-6-methylpicolinate

There total 2 articles about Methyl5-fluoro-6-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2-bromo-5-fluoro-6-methyl-2-pyridine (374633-38-2) + carbon monoxide (201230-82-2) → 5-fluoro-6-methylpyridinecarboxylic acid methyl ester (1245647-61-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 80 ℃; for 16h; under 2585.81 Torr; Inert atmosphere;

Reference yield:

→ 5-fluoro-6-methylpyridinecarboxylic acid methyl ester (1245647-61-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium acetate; at 80 ℃; for 17h; under 3750.38 Torr;

Reference yield: 82.0%

5-fluoro-6-methylpyridinecarboxylic acid methyl ester (1245647-61-3) → 5-fluoro-6-methyl-pyridine-2-carboxylic acid (1005474-88-3)

Guidance literature:

With lithium hydroxide monohydrate; water; In ethanol; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

methanol

2-bromo-5-fluoro-6-methyl-2-pyridine

carbon monoxide

Downstream raw materials:

5-fluoro-6-methyl-pyridine-2-carboxylic acid

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 48. . Retrieved 2013/06/27.