1-((BENZYLOXY)CARBONYL)PIPERIDIN-4-YL METHANESULFONATE

Base Information

• Chemical Name: 1-((BENZYLOXY)CARBONYL)PIPERIDIN-4-YL METHANESULFONATE
• CAS No.: 199103-19-0
• Molecular Formula: C14H19NO5S
• Molecular Weight: 313.375
• Hs Code.: 2933399090
• Mol file: 199103-19-0.mol

Synonyms:4-methanesulfonyloxypiperidine-1-carboxylic acid benzyl ester;

Chemical Property of 1-((BENZYLOXY)CARBONYL)PIPERIDIN-4-YL METHANESULFONATE

Chemical Property:

• Boiling Point: 492.3±44.0 °C(Predicted)
• PKA: -3.07±0.40(Predicted)
• PSA: 81.29000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 2.78250
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl4-((Methylsulfonyl)oxy)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Benzyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate is used as an intermediate for the preparation of conformationally restricted saturated nitrogen heterocyclic sulfonyl chloride.

Technology Process of 1-((BENZYLOXY)CARBONYL)PIPERIDIN-4-YL METHANESULFONATE

There total 6 articles about 1-((BENZYLOXY)CARBONYL)PIPERIDIN-4-YL METHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) + methanesulfonyl chloride (124-63-0) → benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (199103-19-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm501175v

Reference yield: 99.0%

→ benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (199103-19-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

→ benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (199103-19-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1)

Guidance literature:

upstream raw materials:

1-(benzyloxycarbonyl)-4-hydroxypiperidine

methanesulfonyl chloride

4-HYDROXYPIPERIDINE

benzyl chloroformate

Downstream raw materials:

4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester

1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine

4-(acetylthio)-1-(benzyloxycarbonyl)piperidine

Refernces

• 1、 -. "BENZAMIDES OF PYRAZOLYL-AMINO-PYRIMIDINYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF". Paragraph 00571; 00653. . Retrieved 2020/07/07.
• 2、 -. "HOMOBISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE". Page/Page column 49. . Retrieved 2017/07/05.