Technology Process of 2H-Indol-2-one, 5-chloro-1,3-dihydro-3-Methyl-
There total 10 articles about 2H-Indol-2-one, 5-chloro-1,3-dihydro-3-Methyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-chloro-indolin-2-one;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
methyl halide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/chem.201700851
- Guidance literature:
-
With
boric acid; triphenylphosphine; palladium dichloride;
In
tetrahydrofuran;
at 80 ℃;
for 20h;
under 26601.8 Torr;
regioselective reaction;
DOI:10.1021/acscatal.8b02863
- Guidance literature:
-
With
trimethylamine-N-oxide; tricarbonyl(η4-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; potassium carbonate;
at 110 ℃;
for 24h;
DOI:10.1021/acscatal.8b02158