2-(Chloromethyl)-3-fluoropyridine Hydrochloride

Base Information

• Chemical Name: 2-(Chloromethyl)-3-fluoropyridine Hydrochloride
• CAS No.: 149463-07-0
• Molecular Formula: C6H6Cl2FN
• Molecular Weight: 182.025
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00599343
• Mol file: 149463-07-0.mol

Synonyms:2-(Chloromethyl)-3-fluoropyridine Hydrochloride;149463-07-0;2-chloromethyl-3-fluoropyridine hydrochloride;2-(chloromethyl)-3-fluoropyridine;hydrochloride;2-(Chloromethyl)-3-fluoropyridine HCl;2-(Chloromethyl)-3-fluoropyridine, HCl;MFCD19442768;Pyridine, 2-(chloromethyl)-3-fluoro-, hydrochloride (1:1);2-(Chloromethyl)-3-fluoropyridineHydrochloride;SCHEMBL2307470;DTXSID00599343;SBURMLFOEUIZGQ-UHFFFAOYSA-N;AMY18332;2-Chloromethyl-3-Fluoropyridine HCl;AC1446;AKOS015892043;AC-23590;DS-17098;SY013902;DB-063807;CS-0054624;2-chloromethyl-3- fluoropyridine hydrochloride;A884274;2-(Chloromethyl)-3-fluoropyridine--hydrogen chloride (1/1)

Chemical Property of 2-(Chloromethyl)-3-fluoropyridine Hydrochloride

Chemical Property:

• PSA: 12.89000
• LogP: 2.76150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 180.9861327
• Heavy Atom Count: 10
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

2-(Chloromethyl)-3-fluoropyridinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CCl)F.Cl
• Uses: 2-(Chloromethyl)-3-fluoropyridine, HCl

Technology Process of 2-(Chloromethyl)-3-fluoropyridine Hydrochloride

There total 1 articles about 2-(Chloromethyl)-3-fluoropyridine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-fluoropyridin-2-yl)methanol (31181-79-0) → 2-chloromethyl-3-fluoropyridine hydrochloride (149463-07-0)

Guidance literature:

With thionyl chloride; In dichloromethane;

Reference yield: 84.0%

2-chloromethyl-3-fluoropyridine hydrochloride (149463-07-0) + benzyl N-methyl-N-(4-piperidyl)carbamate (553672-39-2) → benzyl N-[1-[(3-fluoro-2-pyridyl)methyl]-4-piperidyl]-N-methylcarbamate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Reflux;

DOI:10.1016/j.bmcl.2019.126933

Reference yield: 52.0%

2-chloromethyl-3-fluoropyridine hydrochloride (149463-07-0) + 2-(4-(2-(2-aminoethoxy)ethoxy)phenyl)-4H-chromen-4-one → 2-(4-(2-(2-(bis((3-fluoropyridin-2-yl)methyl)amino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1128/AAC.02165-20

upstream raw materials:

(3-fluoropyridin-2-yl)methanol

Downstream raw materials:

2-(3-fluoropyridin-2-yl)acetonitrile

Refernces