N-methyl-2,3-dihydro-1H-inden-2-amine

Base Information

• Chemical Name: N-methyl-2,3-dihydro-1H-inden-2-amine
• CAS No.: 24445-44-1
• Molecular Formula: C10H13N
• Molecular Weight: 147.22
• Hs Code.: 2921499090
• UNII: ZLW84Y27HG
• ChEMBL ID: CHEMBL1188235
• DSSTox Substance ID: DTXSID901010100
• Wikidata: Q20707155
• Wikipedia: NM-2-AI
• Mol file: 24445-44-1.mol

Synonyms:24445-44-1;N-methyl-2,3-dihydro-1H-inden-2-amine;n-methyl-2-aminoindane;INDAN-2-YL-METHYLAMINE;NM-2-AI;N-Methylindan-2-amine;NM2AI;2,3-dihydro-1H-inden-2-yl(methyl)amine;ZLW84Y27HG;UNII-ZLW84Y27HG;JPC 6811;2,3-Dihydro-1H-Inden-2-Yl(Methyl)Amine(Saltdata: Hcl);N-methyl-2-AI (hydrochloride);N-2,3-dihydro-1H-inden-2-yl-N-methylamine;1H-Inden-2-amine, 2,3-dihydro-N-methyl-;N-Methyl-2-indanamine;2-(N-methyl)aminoindan;Indan-2-yl -methyl-amine;SCHEMBL714537;CHEMBL1188235;SXWZQUCTTOBHJT-UHFFFAOYSA-N;DTXSID901010100;JPC-6811;MFCD12027038;AKOS005171377;AB18567;NCGC00337276-01;NS00017659;D86972;AB01206867-03;N-(2,3-DIHYDRO-1H-INDEN-2-YL)-N-METHYLAMINE;Q20707155

Chemical Property of N-methyl-2,3-dihydro-1H-inden-2-amine

Chemical Property:

• Boiling Point: 236.352 °C at 760 mmHg
• PKA: 9.97±0.20(Predicted)
• Flash Point: 97.79 °C
• PSA: 12.03000
• Density: 1.016 g/cm³
• LogP: 2.56610
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 147.104799419
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

99% ^*data from raw suppliers

N-methyl-2,3-dihydro-1H-inden-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1CC2=CC=CC=C2C1

Technology Process of N-methyl-2,3-dihydro-1H-inden-2-amine

There total 8 articles about N-methyl-2,3-dihydro-1H-inden-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indan-2-yl-carbamic acid ethyl ester (24446-27-3) → N-Methyl-2-aminoindane (24445-44-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

Reference yield:

carbamate 2-(ethoxycarbonyl-amino)indane → N-Methyl-2-aminoindane (24445-44-1)

Guidance literature:

With sodium hydroxide; LiAlH₄; In diethyl ether; water;

Reference yield:

tert‐butyl (2,3‐dihydro‐1H‐inden‐2‐yl)carbamate → N-Methyl-2-aminoindane (24445-44-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Inert atmosphere; Cooling with ice; Reflux;

upstream raw materials:

2-indanone

methylamine

dimethyl sulfate

2,3-dihydro-1H-inden-2-amine

Downstream raw materials:

2-N-n-Propylaminoindan

benzyl-indan-2-yl-methyl-amine; hydrochloride

4-[N-(indan-2-yl)-N-methyl]aminomethyl-1-benzoylpiperidine hydrochloride

Refernces

• 1、 -. "INHIBITORS OF PROLYL-TRNA-SYNTHETASE". Sheet 6. . Retrieved 2019/12/28.
• 2、 Fotsch,Sonnenberg,Chen,Hale,Karbon,Norman. "Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists". . p. 2344 - 2356. Retrieved 2007/10/03.