2,4-Dichloro-6-methoxyquinoline

Base Information

• Chemical Name: 2,4-Dichloro-6-methoxyquinoline
• CAS No.: 70049-46-6
• Molecular Formula: C10H7Cl2NO
• Molecular Weight: 228.078
• Hs Code.: 2933499090
• European Community (EC) Number: 821-414-5
• DSSTox Substance ID: DTXSID00359166
• Nikkaji Number: J1.623.224F
• Wikidata: Q72466716
• ChEMBL ID: CHEMBL1906027
• Mol file: 70049-46-6.mol

Synonyms:2,4-dichloro-6-methoxyquinoline;70049-46-6;2,4-Dichloro-6-methoxy-quinoline;MLS000767600;QUINOLINE, 2,4-DICHLORO-6-METHOXY-;SMR000430028;SCHEMBL830265;cid_948356;CHEMBL1906027;BDBM69489;DTXSID00359166;FUAYQQYYACASFP-UHFFFAOYSA-N;HMS2778I13;MFCD03285967;STK540916;AKOS005470734;AB13973;DS-1908;2,4-bis(chloranyl)-6-methoxy-quinoline;FT-0718146;EN300-255594

Chemical Property of 2,4-Dichloro-6-methoxyquinoline

Chemical Property:

• Boiling Point: 327.9±37.0 °C(Predicted)
• PKA: -1.09±0.50(Predicted)
• PSA: 22.12000
• Density: 1.384±0.06 g/cm3(Predicted)
• LogP: 3.55020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 226.9904692
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-6-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)N=C(C=C2Cl)Cl

Technology Process of 2,4-Dichloro-6-methoxyquinoline

There total 7 articles about 2,4-Dichloro-6-methoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-hydroxy-6-methoxy-1H-quinolin-2-one (14300-45-9) → 2,4-dichloro-6-methoxyquinoline (70049-46-6)

Guidance literature:

With trichlorophosphate; for 8h; Reflux;

DOI:10.1002/jhet.1865

Reference yield: 72.0%

malonic acid (141-82-2) + 4-methoxy-aniline (104-94-9) → 2,4-dichloro-6-methoxyquinoline (70049-46-6)

Guidance literature:

With trichlorophosphate; Heating;

Reference yield: 72.0%

2,4-Dichloro-6-methoxy-quinoline-3-carbaldehyde (151772-24-6) → 2,4-dichloro-6-methoxyquinoline (70049-46-6)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1055/s-1993-25914

upstream raw materials:

2,4-Dichloro-6-methoxy-quinoline-3-carbaldehyde

malonic acid

4-methoxy-aniline

2-methoxy-phenylamine

Downstream raw materials:

2,4-Dichloro-6-methoxy-quinoline-3-carbaldehyde

2-chloro-4,6-dimethoxyquinoline

4-(4-fluoro-6-hydroxyquinolin-2-yl)-3-methoxybenzoic acid

methyl 4-(4-amino-6-methoxyquinolin-2-yl)benzoate

Refernces

• 1、 Mostafa, Sara M.,Aly, Ashraf A.,Sayed, Samia M.,Raslan, Mohamed A.,Ahmed, Amira E.,Nafady, Ayman,Ishak, Esam A.,Shawky, Ahmed M.,Abdelhafez, El-Shimaa M.N.. "New Quinoline-2-one/thiazolium bromide Derivatives; Synthesis, Characterization and Mechanism of Formation". . . Retrieved 2021/05/10.
• 2、 Clark, Robert D.,Morris, Denise N.,Chinigo, Gary,Lawless, Michael S.,Prudhomme, Jacques,Le Roch, Karine G.,Lafuente, Maria José,Ferrer, Santiago,Gamo, Francisco Javier,Gadwood, Robert,Woltosz, Walter S.. "Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones". . p. 1117 - 1132. Retrieved 2020/08/26.