Pyrrolidin-1-yl(4-(trifluoromethyl)phenyl)methanone

Base Information

• Chemical Name: Pyrrolidin-1-yl(4-(trifluoromethyl)phenyl)methanone
• CAS No.: 447431-60-9
• Molecular Formula: C₁₂H₁₂F₃NO
• Molecular Weight: 243.229
• Mol file: 447431-60-9.mol

Synonyms:

Chemical Property of Pyrrolidin-1-yl(4-(trifluoromethyl)phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidin-1-yl(4-(trifluoromethyl)phenyl)methanone

There total 14 articles about Pyrrolidin-1-yl(4-(trifluoromethyl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pyrrolidine (123-75-1) + t-butyl benzyl(4-(trifluoromethyl)benzoyl)carbamate → (pyrrolidin-1-yl)(4-(trifluoromethyl)phenyl)methanone (447431-60-9)

Guidance literature:

With air; In toluene; at 100 ℃; for 24h; Molecular sieve;

Reference yield: 97.0%

pyrrolidine (123-75-1) + 4-trifluoromethyl-phenyl acetyl chloride (329-15-7) → (pyrrolidin-1-yl)(4-(trifluoromethyl)phenyl)methanone (447431-60-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02414

Reference yield: 97.0%

pyrrolidine (123-75-1) + tert-butyl methyl(4-(trifluoromethyl)benzoyl)carbamate → (pyrrolidin-1-yl)(4-(trifluoromethyl)phenyl)methanone (447431-60-9)

Guidance literature:

In ethanol; at 45 ℃; chemoselective reaction; Sealed tube;

DOI:10.1055/s-0037-1610664

upstream raw materials:

pyrrolidine

4-trifluoromethyl-phenyl acetyl chloride

4-trifluoromethylbenzoic acid

1-(prop-2-ene-1-sulfinyl)pyrrolidine

Downstream raw materials:

(2-(1,2-diphenylvinyl)-4-trifluoromethylphenyl)pyrrolidin-1-ylmethanone

C₂₆H₂₅F₃N₂O₃S

N-(4-methylphenyl)-4-(trifluoromethyl)benzamide

Refernces

• 1、 Ghinato, Simone,Territo, Davide,Maranzana, Andrea,Capriati, Vito,Blangetti, Marco,Prandi, Cristina. "A Fast and General Route to Ketones from Amides and Organolithium Compounds under Aerobic Conditions: Synthetic and Mechanistic Aspects". supporting information. p. 2868 - 2874. Retrieved 2021/01/21.
• 2、 Bian, Fengxia,Cheng, Hongmei,Jiang, Heyan,Sun, Bin,Tan, Jiangwei,Zang, Cuicui. "Photocatalytic aldehydes/alcohols/toluenes oxidative amidation over bifunctional Pd/MOFs: Effect of Fe-O clusters and Lewis acid sites". . p. 279 - 287. Retrieved 2021/08/21.