Technology Process of Acetamide, N-(3-amino-2-fluorophenyl)-
There total 2 articles about Acetamide, N-(3-amino-2-fluorophenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; cyclohexene;
In
ethanol;
at 60 ℃;
for 21h;
Inert atmosphere;
DOI:10.1021/jm201596h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / 16 h / 20 °C
2: palladium 10% on activated carbon; cyclohexene / ethanol / 21 h / 60 °C / Inert atmosphere
With
palladium 10% on activated carbon; cyclohexene;
In
pyridine; ethanol;
DOI:10.1021/jm201596h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: ethanol / 24 h / Reflux
1.2: 4 h / 20 °C
2.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice
3.1: thionyl chloride / 2 h / 20 °C
4.1: potassium carbonate / acetonitrile / 2 h / 80 °C
5.1: hydrogenchloride / 1 h / 100 °C
6.1: N,N-dimethyl acetamide / 5 h
7.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane / 5 h / 85 °C / Inert atmosphere
With
hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; sodium carbonate; potassium carbonate;
In
1,2-dimethoxyethane; ethanol; N,N-dimethyl acetamide; acetonitrile;
7.1: Suzuki coupling;
DOI:10.1021/jm201596h
