Methyl2,4-dichlorothiazole-5-carboxylate

Base Information

• Chemical Name: Methyl2,4-dichlorothiazole-5-carboxylate
• CAS No.: 861708-66-9
• Molecular Formula: C5H3Cl2NO2S
• Molecular Weight: 212.056
• Hs Code.: 2934100090
• Mol file: 861708-66-9.mol

Synonyms:Methyl2,4-dichlorothiazole-5-carboxylate;2,4-Dichloro-5-thiazolecarboxylic acid methyl ester;5-Thiazolecarboxylic acid, 2,4-dichloro-, Methyl ester

Chemical Property of Methyl2,4-dichlorothiazole-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.000671mmHg at 25°C
• Boiling Point: 309℃
• PKA: -3.86±0.10(Predicted)
• Flash Point: 141℃
• PSA: 67.43000
• Density: 1.583
• LogP: 2.23650
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Heated), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

methyl2,4-dichlorothiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl2,4-dichlorothiazole-5-carboxylate

There total 1 articles about Methyl2,4-dichlorothiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4-dichloro-thiazole-5-carboxylic acid (62019-56-1) + methyl iodide (74-88-4) → methyl 2,4-dichlorothiazole-5-carboxylate (861708-66-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield: 52.0%

methyl 2,4-dichlorothiazole-5-carboxylate (861708-66-9) + 4-methoxyphenylboronic acid (5720-07-0) → 5-thiazolecarboxylic methyl ester 4-chloro-2-[4-methoxy-phenyl] (861708-67-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 5h; Inert atmosphere;

Reference yield: 43.0%

methyl 2,4-dichlorothiazole-5-carboxylate (861708-66-9) + 3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → 4-Chloro-5-methoxycarbonyl-2-(3-methoxyphenyl) thiazole (861708-69-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 5h; Inert atmosphere;

upstream raw materials:

2,4-dichloro-thiazole-5-carboxylic acid

methyl iodide

Downstream raw materials:

5-thiazolecarboxylic methyl ester 4-chloro-2-[4-methoxy-phenyl]

4-Chloro-5-methoxycarbonyl-2-(3-methoxyphenyl) thiazole

5-thiazolecarboxylic methyl ester 4-chloro-2-[4-chloro-phenyl]

4-anilino-5-methoxycarbonyl-2-(4-methoxyphenyl) thiazole

Refernces