3-(Fluoromethyl)fluorobenzene

Base Information

• Chemical Name: 3-(Fluoromethyl)fluorobenzene
• CAS No.: 2267-30-3
• Molecular Formula: C7H6F2
• Molecular Weight: 128.121
• Mol file: 2267-30-3.mol

Synonyms:3-fluoro-benzoic acid cyclohexylamide;3-Fluor-benzylfluorid;1-Fluoro-3-(fluoromethyl)benzene;3-fluoro-benzyl fluoride;3-Fluor-benzoesaeure-cyclohexylamid;N-CYCLOHEXYL 3-FLUOROBENZAMIDE;

Chemical Property of 3-(Fluoromethyl)fluorobenzene

Chemical Property:

• PSA: 0.00000
• LogP: 2.76330

Purity/Quality:

98.5% ^*data from raw suppliers

1-Fluoro-3-(fluoromethyl)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Fluoromethyl)fluorobenzene

There total 6 articles about 3-(Fluoromethyl)fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

m-Fluorotoluene (352-70-5) → 3-fluoro-benzyl fluoride (2267-30-3)

Guidance literature:

With caesium fluoroxysulphate; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1016/S0022-1139(00)80337-1

Reference yield: 10.0%

m-Fluorotoluene (352-70-5) → 1,4-difluoro-2-methylbenzene (452-67-5) + 3-fluoro-benzyl fluoride (2267-30-3) + 1-Methyl-3,3,6-trifluoro-1,4-cyclohexadiene (205597-62-2) + 1-Methyl-3,3,6,6,-tetrafluoro-1,4-cyclohexadiene

Guidance literature:

With tetraethylammonium fluoride; In acetonitrile; Ambient temperature; electrolysis: smooth platinum sheets as the anode and the cathode, Ag/AgClO₄ as a reference electrode, 2.3 V;

DOI:10.1016/S0022-1139(97)00141-3

Reference yield:

1-(Bromomethyl)-3-fluorobenzene (456-41-7) → 3-fluoro-benzyl fluoride (2267-30-3)

Guidance literature:

With pyridine; mercury(II) fluoride; chloroform; at 35 ℃;

DOI:10.1021/ja01187a003

upstream raw materials:

1-(Bromomethyl)-3-fluorobenzene

m-Fluorotoluene

3-fluoro-benzenemethanol

m-fluorobenzyl chloride

Refernces

• 1、 Stavber, Stojan,Planinsek, Zdenka,Kosir, Iztok,Zupan, Marko. "Substituent modulation of mild fluorination of aromatic molecules with caesium fluoroxysulphate". . p. 409 - 412. Retrieved 2007/10/02.