Azetidine, 3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-

Base Information

• Chemical Name: Azetidine, 3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-
• CAS No.: 79201-18-6
• Molecular Formula: C12H17NO2S
• Molecular Weight: 239.338
• Mol file: 79201-18-6.mol

Synonyms:

Chemical Property of Azetidine, 3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Azetidine, 3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-

There total 11 articles about Azetidine, 3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

2,2-dimethyl-3-(p-toluenesulfonamido)-1-propanol p-toluenesulfonate (79201-17-5) → 3,3-dimethyl-N-<4-methylphenylsulfonyl>azetidine (79201-18-6)

Guidance literature:

With potassium; In tert-butyl alcohol; for 12.3h; Heating;

DOI:10.1021/jo00337a016

Reference yield: 46.0%

toluene-4-sulfonamide (70-55-3) → 3,3-dimethyl-N-<4-methylphenylsulfonyl>azetidine (79201-18-6)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

C22H25NO2STi → 3,3-dimethyl-N-<4-methylphenylsulfonyl>azetidine (79201-18-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; toluene; at -10 - 20 ℃; for 6h;

DOI:10.1002/anie.202103278

upstream raw materials:

2,2-dimethyl-3-(p-toluenesulfonamido)-1-propanol p-toluenesulfonate

3,3-dimethyl azetidine

p-toluenesulfonyl chloride

3-hydroxy-2,2-dimethylpropionitrile

Downstream raw materials:

3,3-dimethylazetidine hydrochloride

2-(3,3-dimethyl-1-azetidinylmethyl)phenylboronic acid

3,3-dimethyl-1-(phenylmethyl)azetidine

3,3-dimethyl azetidine

Refernces

• 1、 -. "9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS". Page/Page column. . Retrieved 2014/07/08.
• 2、 Hansen, Camilla P.,Jensen, Anders A.,Christensen, Jeppe K.,Balle, Thomas,Liljefors, Tommy,Fr?lund, Bente. "Novel acetylcholine and carbamoylcholine analogues: Development of a functionally selective α4β2 nicotinic acetylcholine receptor agonist". scheme or table. p. 7380 - 7395. Retrieved 2009/12/07.