(2-Fluoro-6-iodophenyl)methanol

Base Information

• Chemical Name: (2-Fluoro-6-iodophenyl)methanol
• CAS No.: 911825-94-0
• Molecular Formula: C7H6FIO
• Molecular Weight: 252.027
• Hs Code.: 2906290090
• Mol file: 911825-94-0.mol

Synonyms:(3-FLUORO-1,2-PHENYLENE)DIMETHANOL;(2-flioro-6-iodophenyl)methanol;3-fluoro-1,2-di-(hydroxymethyl)benzene;(2-fluoro-6-hydroxymethyl-phenyl)-methanol;1,2-benzenedimethanol,3-fluoro;3-fluorobenzene-1,2-dimethanol;

Chemical Property of (2-Fluoro-6-iodophenyl)methanol

Chemical Property:

• PSA: 20.23000
• LogP: 1.92260

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-6-iodobenzyl alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Fluoro-6-iodophenyl)methanol

There total 1 articles about (2-Fluoro-6-iodophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-fluoro-6-iodobenzoic acid (111771-08-5) → (2-flioro-6-iodophenyl)methanol (911825-94-0)

Guidance literature:

With Trimethyl borate; dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03577

Reference yield: 95.0%

(2-flioro-6-iodophenyl)methanol (911825-94-0) → 6-fluoro-2-iodobenzaldehyde (146137-72-6)

Guidance literature:

With dipyridinium dichromate; silica gel; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03577

Reference yield: 84.0%

(2-flioro-6-iodophenyl)methanol (911825-94-0) + 3-Chloro-2-methylpropene (563-47-3) → 1-fluoro-3-iodo-2-(((2-methylallyl)oxy)methyl)benzene

Guidance literature:

(2-flioro-6-iodophenyl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.75h; Inert atmosphere;

3-Chloro-2-methylpropene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3.33h; Inert atmosphere;

DOI:10.1002/anie.201400807

upstream raw materials:

2-fluoro-6-iodobenzoic acid

Downstream raw materials:

2-(Allyloxymethyl)-1-fluoro-3-iodobenzene

6-fluoro-2-iodobenzaldehyde

Refernces

• 1、 Whyte, Andrew,Olson, Maxwell E.,Lautens, Mark. "Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation". supporting information. p. 345 - 348. Retrieved 2018/01/27.
• 2、 Wang, Liang,Li, Xuehu,Tao, Hua,Zhou, Xiang,Lu, Xihong,Du, Wenyue,Jiang, Tingting,Xin, Zhijun,Liang, Jianping. "Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds". supporting information. p. 2403 - 2410. Retrieved 2017/03/20.