Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98%

Base Information

• Chemical Name: Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98%
• CAS No.: 1163287-01-1
• Molecular Formula: C9H8FNO4
• Molecular Weight: 213.165
• Hs Code.: 2916399090
• Mol file: 1163287-01-1.mol

Synonyms:5-Fluoro-2-(methoxycarbonyl)-4-nitrotoluene, 2-Fluoro-5-(methoxycarbonyl)-4-methylnitrobenzene;

Chemical Property of Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98%

Chemical Property:

• Boiling Point: 320.2±37.0 °C(Predicted)
• PSA: 72.12000
• Density: 1.335
• LogP: 2.35210
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl4-Fluoro-2-methyl-5-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98%

There total 5 articles about Methyl 4-fluoro-2-methyl-5-nitrobenzoate 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-fluoro-2-methyl benzoic acid methyl ester (174403-69-1) → methyl 4-fluoro- 2-methyl-5-nitrobenzoate (1163287-01-1)

Guidance literature:

With sulfuric acid; potassium nitrate; at -20 - -10 ℃; for 0.666667h;

Reference yield:

methanol (67-56-1) + 4-fluoro-2-methylbenzoic acid (321-21-1) → methyl 4-fluoro-2-methyl-3-nitrobenzoate (1079991-69-7) + methyl 4-fluoro- 2-methyl-5-nitrobenzoate (1163287-01-1)

Guidance literature:

4-fluoro-2-methylbenzoic acid; With nitric acid; acetic acid; at 20 - 80 ℃; for 6h; Inert atmosphere;

methanol; With sulfuric acid; at 0 ℃; for 48h; Overall yield = 6 g; Inert atmosphere; Reflux;

Reference yield:

4-fluoro-2-methyl benzoic acid methyl ester (174403-69-1) → methyl 4-fluoro-2-methyl-3-nitrobenzoate (1079991-69-7) + methyl 4-fluoro- 2-methyl-5-nitrobenzoate (1163287-01-1)

Guidance literature:

With sulfuric acid; potassium nitrate; at -10 ℃; for 4.16667h;

upstream raw materials:

4-fluoro-2-methyl benzoic acid methyl ester

4-fluoro-2-methylbenzoic acid

methanol

4-fluoro-2-methyl-5-nitrobenzoic acid

Downstream raw materials:

7-nitro-2-[3-(2-oxooxazolidin-3-yl)propyl]-6-(4-o-tolylpiperazin-1-yl)-2H-isoquinolin-1-one

C₂₃H₂₈N₄O₄

C₂₀H₂₃N₃O₄

methyl 5-amino-2-methyl-4-(methylamino)benzoate

Refernces

• 1、 -. "HEPATITIS B CORE PROTEIN MODULATORS". Page/Page column 146; 147. . Retrieved 2018/04/13.
• 2、 -. "BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE". . . Retrieved 2013/07/25.