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Technology Process of 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one

1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one

Base Information Edit
  • Chemical Name:1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one
  • CAS No.:314245-33-5
  • Molecular Formula:C18H21FN2O
  • Molecular Weight:300.376
  • Hs Code.:2933990090
  • European Community (EC) Number:686-043-1
  • DSSTox Substance ID:DTXSID80350196
  • Nikkaji Number:J2.866.960G
  • Wikidata:Q82126010
  • Pharos Ligand ID:PDYH34PLC5QV
  • ChEMBL ID:CHEMBL1410015
  • Mol file:314245-33-5.mol
1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one

Synonyms:1-(1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl)-2-pyrrolidin-1-ylethanone;IU1 compound

Suppliers and Price of 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • IU1
  • 10mg
  • $ 423.00
  • TRC
  • IU1
  • 10mg
  • $ 55.00
  • TRC
  • IU1
  • 25mg
  • $ 120.00
  • Sigma-Aldrich
  • IU1 ≥98% (HPLC)
  • 5mg
  • $ 119.00
  • Sigma-Aldrich
  • IU1 ≥98% (HPLC)
  • 25mg
  • $ 456.00
  • Medical Isotopes, Inc.
  • IU1
  • 50 mg
  • $ 1040.00
  • Medical Isotopes, Inc.
  • IU1
  • 10 mg
  • $ 635.00
  • DC Chemicals
  • IU1 >98%
  • 250 mg
  • $ 950.00
  • Crysdot
  • IU1 95+%
  • 1g
  • $ 1410.00
  • ChemScene
  • IU1 99.45%
  • 5mg
  • $ 60.00
Total 21 raw suppliers
Chemical Property of 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one Edit
Chemical Property:
  • Boiling Point:437.034 °C at 760 mmHg 
  • PKA:8.20±0.20(Predicted) 
  • Flash Point:218.111 °C 
  • PSA：25.24000 
  • Density:1.169 g/cm3 
  • LogP:3.44960 
  • Storage Temp.:Store at +4°C 
  • Solubility.:DMSO: >10mg/mL 
  • XLogP3:3.5
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:4
  • Exact Mass:300.16379146
  • Heavy Atom Count:22
  • Complexity:389
Purity/Quality:

98.0%Min *data from raw suppliers

IU1 *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xi 
  • Hazard Codes:Xi 
  • Statements: 41 
  • Safety Statements: 61 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3
  • Description IU1 (314245-33-5) is a selective inhibitor of USP14 (IC50<4 μM). Enhances proteasome activity and substrate proteolysis.1,2 Inhibits Dengue virus replication.3 In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load.4 Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model.5 Cell permeable.
  • Uses IU1 has been used for the inhibition of Ubiquitin Specific Peptidase 14 (USP14) in human neuroblastoma cells (SH-SY5Y) and in ubiquitin-rhodamine hydrolysis plate assay.

Total 8 Pictures about this product

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