5-Bromo-2-methoxyisonicotinaldehyde

Base Information

• Chemical Name: 5-Bromo-2-methoxyisonicotinaldehyde
• CAS No.: 936011-17-5
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.03204
• Hs Code.: 2933399090
• Mol file: 936011-17-5.mol

Synonyms:5-Bromo-2-methoxyisonicotinaldehyde

Chemical Property of 5-Bromo-2-methoxyisonicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Boiling Point: 273.596°C at 760 mmHg
• Flash Point: 119.267°C
• PSA: 39.19000
• Density: 1.606g/cm³
• LogP: 1.66520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-bromo-2-methoxyisonicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-methoxyisonicotinaldehyde

There total 3 articles about 5-Bromo-2-methoxyisonicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2-methoxy-pyridine-4-carbaldehyde (936011-17-5)

Guidance literature:

2-methoxy-5-bromopyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -5 ℃; for 0.5h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 3h; Inert atmosphere;

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-bromo-2-methoxy-pyridine-4-carbaldehyde (936011-17-5)

Guidance literature:

2-methoxy-5-bromopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 5-bromo-2-methoxy-pyridine-4-carbaldehyde (936011-17-5)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃;

upstream raw materials:

N,N-dimethyl-formamide

2-methoxy-5-bromopyridine

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

(5aR,6S,6aS)-ethyl 3-((2’,6’-dimethyl-4’-(3-(methylsulfonyl)propoxy)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Refernces

• 1、 -. "P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF". Paragraph 0247-0248. . Retrieved 2020/12/10.
• 2、 -. "HEMOGLOBIN MODIFIER COMPOUNDS AND USES THEREOF". Paragraph 00600. . Retrieved 2018/02/28.