(5,6,8,9,11,12,14,15-3H)Arachidonic acid

Base Information

• Chemical Name: (5,6,8,9,11,12,14,15-3H)Arachidonic acid
• CAS No.: 66753-05-7
• Molecular Formula: C20H32O2
• Molecular Weight: 320.5318
• Nikkaji Number: J344.569K
• Mol file: 66753-05-7.mol

Synonyms:66753-05-7;(5,6,8,9,11,12,14,15-3H)Arachidonic acid;5,8-11,14-Eicosatetraenoic 5,6,8,9,11,12,14,15-t8 acid, (all-Z)-;C20H24O2T8;ARACHIDONIC ACID, [5,6,8,9,11,12,14,15-3H(N)]-;C20-H24-O2-T8;(5Z,8Z,11Z,14Z)-5,6,8,9,11,12,14,15-octatritioicosa-5,8,11,14-tetraenoic acid;Arachidonic acid,[5,6,8,9,11,12,14,15-3h(N)]-

Chemical Property of (5,6,8,9,11,12,14,15-3H)Arachidonic acid

Chemical Property:

• Vapor Pressure: 8.85E-08mmHg at 25°C
• Boiling Point: 407.4°Cat760mmHg
• Flash Point: 336.3°C
• PSA: 37.30000
• Density: g/cm³
• LogP: 6.21670
• Storage Temp.: −20°C
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 14
• Exact Mass: 320.306024255
• Heavy Atom Count: 22
• Complexity: 362

Purity/Quality:

99% ^*data from raw suppliers

ARACHIDONIC ACID[5,6,8,9,11,12,14,15-3H(N)] 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi,R
• Hazard Codes: F,Xi,R
• Statements: 11-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)O
• Isomeric SMILES: [3H]/C(=C(\[3H])/C/C(=C(/[3H])\C/C(=C(/[3H])\C/C(=C(/[3H])\CCCC(=O)O)/[3H])/[3H])/[3H])/CCCCC

Technology Process of (5,6,8,9,11,12,14,15-3H)Arachidonic acid

There total 1 articles about (5,6,8,9,11,12,14,15-3H)Arachidonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

eicosa-5,8,11,14-tetraynoic acid (1191-85-1) → <5,6,8,9,11,12,14,15-3H8>arachidonic acid (66753-05-7)

Guidance literature:

With tritium; Lindlar's catalyst; In 1,4-dioxane; at 20 ℃; for 2h; under 300.024 Torr;

DOI:10.1002/jlcr.663

Reference yield: 91.0%

dopamine (51-61-6) + <5,6,8,9,11,12,14,15-3H8>arachidonic acid (66753-05-7) → N-[5,6,8,9,11,12,14,15-3H8]arachidonoyl-3-hydroxytyramine

Guidance literature:

<5,6,8,9,11,12,14,15-3H8>arachidonic acid; With triethylamine; isobutyl chloroformate; In acetonitrile; at 23 ℃; for 2h;

dopamine; In N,N-dimethyl-formamide; at 23 ℃; for 20h;

DOI:10.1002/jlcr.663

Reference yield: 77.0%

<5,6,8,9,11,12,14,15-3H8>arachidonic acid (66753-05-7) → [5,6,8,11,12,14,15-(3)H]-prostaglandin E2 (84807-93-2)

Guidance literature:

With hemin; GLUTATHIONE; L-epinephrine; PG synthase; PGE synthase; In ethanol; at 23 ℃; for 1h; pH=7.4; Enzymatic reaction;

DOI:10.1002/(SICI)1099-1344(1998080)41:8<741::AID-JLCR123>3.0.CO;2-W

upstream raw materials:

eicosa-5,8,11,14-tetraynoic acid

Downstream raw materials:

[5,6,8,11,12,14,15-(3)H]-prostaglandin E₂

Leukotriene B

6-trans-Leukotriene B₄

5(S)-HETE

Refernces