2,6-Dimethylaniline-D6

Base Information

• Chemical Name: 2,6-Dimethylaniline-D6
• CAS No.: 919785-81-2
• Molecular Formula: (CD3)2C6H3NH2
• Molecular Weight: 127.134
• Mol file: 919785-81-2.mol

Synonyms:2,6-Dimethylaniline-d6;2,6-di(d3-methyl)aniline;2,5-DIMETHOXYPHENETHYLAMINE,COLORLESS OIL;

Chemical Property of 2,6-Dimethylaniline-D6

Chemical Property:

• PSA: 26.02000
• LogP: 2.46680
• Storage Temp.: Refrigerator, Under Inert Atmosphere

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dimethylaniline-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled metabolite of N-(2-6-Dimethylphenyl)-5methyl-3-isoxazolecarboxamide (D2624). Labelled Bupivacaine (B689560) impurity.

Technology Process of 2,6-Dimethylaniline-D6

There total 1 articles about 2,6-Dimethylaniline-D6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,6-dimethylaniline (87-62-7) → 2,6-di(d3-methyl)aniline (919785-81-2)

Guidance literature:

With C₄₀H₅₁ClIrN₃; potassium carbonate; deuterium; In dichloromethane; at 50 ℃; for 12h; under 760.051 Torr; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00402

Reference yield: 75.0%

2,6-di(d3-methyl)aniline (919785-81-2) + <2-2H2>-2-chloroacetyl chloride (159301-43-6) → 2-chloro-N-(2,6-di(d3-methyl)phenyl)-2,2-d2-acetamide (1054624-86-0)

Guidance literature:

With triethylamine; In toluene; at 0 - 20 ℃; for 2h;

upstream raw materials:

2,6-dimethylaniline

Downstream raw materials:

2-chloro-N-(2,6-di(d3-methyl)phenyl)-2,2-d2-acetamide

Refernces