Propionyl-d5 Chloride

Base Information

• Chemical Name: Propionyl-d5 Chloride
• CAS No.: 352439-04-4
• Molecular Formula: CD3CD2COCl
• Molecular Weight: 97.56
• Mol file: 352439-04-4.mol

Synonyms:d5-N-ethylmaleimide;d5-propionyl chloride;d5-3-nitro-4-phenoxy-5-sulfamoyl-benzoic acid;

Chemical Property of Propionyl-d5 Chloride

Chemical Property:

• PSA: 17.07000
• LogP: 1.16180

Purity/Quality:

99% ^*data from raw suppliers

Propanoyl-D5 Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propionyl-d5 Chloride

There total 1 articles about Propionyl-d5 Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propionic acid-d5 (60153-92-6) → d5-propionyl chloride (352439-04-4)

Guidance literature:

With phosphorus pentachloride; for 3h; Inert atmosphere;

DOI:10.1002/anie.202016070

Reference yield:

d5-propionyl chloride (352439-04-4) + d18-(1-benzyl-4-methoxymethyl-piperidin-4-yl)-phenyl-amine (1204688-32-3) → d23-N-(1-benzyl-4-methoxymethyl-piperidin-4-yl)-N-phenyl-propionamide (1204688-33-4)

Guidance literature:

d5-propionyl chloride; d18-(1-benzyl-4-methoxymethyl-piperidin-4-yl)-phenyl-amine; In dichloromethane; at 20 - 26 ℃;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

propionic acid-d5

Downstream raw materials:

d23-N-(1-benzyl-4-methoxymethyl-piperidin-4-yl)-N-phenyl-propionamide

Refernces