Technology Process of 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone
There total 1 articles about 2-(6-Methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-dimethylpyridine;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -60 ℃;
for 0.5h;
With
diethylaluminium chloride;
In
tetrahydrofuran; hexane;
at -60 - 20 ℃;
quinoxaline-6-carbonyl chloride;
In
tetrahydrofuran; hexane;
at -60 ℃;
for 0.333333h;
Further stages.;
DOI:10.1021/jm070129k
DOI:10.1016/j.bmcl.2008.01.084
- Guidance literature:
-
With
aq. HBr;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C
2.1: 83 percent / various solvent(s); methanol; H2O / 3 h / 20 °C
3.1: 94 percent / aq. HCl / 3 h / 70 °C
4.1: AcOH / 1,2-dichloro-ethane / 1 h / 20 °C
4.2: 48 percent / sodium triacetoxyborohydride / 1,2-dichloro-ethane / 20 °C
With
hydrogenchloride; hydrogen bromide; acetic acid; dimethyl sulfoxide;
In
methanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm070129k