(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone

Base Information

• Chemical Name: (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone
• CAS No.: 613678-03-8
• Molecular Formula: C12H17N3O
• Molecular Weight: 219.286
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20464746
• Wikidata: Q82290210
• Mol file: 613678-03-8.mol

Synonyms:QC-923;

Chemical Property of (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone

Chemical Property:

• Boiling Point: 385.1±42.0 °C(Predicted)
• PKA: 8.15±0.10(Predicted)
• PSA: 59.22000
• Density: 1.153±0.06 g/cm3(Predicted)
• LogP: 1.70740
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 219.137162174
• Heavy Atom Count: 16
• Complexity: 249

Purity/Quality:

98%Min ^*data from raw suppliers

(6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CCC(CC1)C(=O)C2=NC(=CC=C2)N

Technology Process of (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone

There total 17 articles about (6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

(6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone (613678-08-3) → (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone (613678-03-8)

Guidance literature:

With copper(I) oxide; ammonium chloride; sodium hydroxide; In 1,2-dimethoxyethane; at 85 ℃; for 2h; Reagent/catalyst; Solvent; Temperature;

Reference yield: 95.0%

2,2-dimethyl-N-[6-(1-methylpiperidin-4-carbonyl)-2-pyridyl]propanamide → (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone (613678-03-8)

Guidance literature:

With hydrogenchloride; Reagent/catalyst; Reflux;

Reference yield: 92.3%

C13H16ClNO → (6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone (613678-03-8)

Guidance literature:

With copper(I) oxide; ammonium chloride; sodium hydroxide; In 1,2-dimethoxyethane; at 85 ℃; for 2h;

upstream raw materials:

(6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

2-chloropyridine

1-methyl-piperidine-4-carboxylic acid methoxy-methyl-amide

6-Chloro-2-pyridyl 1-methyl-4-piperidinyl ketone

Downstream raw materials:

2,4,6-trifluoro-N-[6-(1-methylpiperidin-4-ylcarbonyl)-pyridin-2-yl]benzamide hydrochloride

Lasmiditan

Refernces

• 1、 -. "2,2-DIMETHYL-N-[6-(1-METHYL-PIPERIDIN-4-CARBONYL)-PYRIDIN-2-YL]-PROPIONAMIDE, METHOD FOR PREPARING (6-AMINO-PYRIDIN-2-YL)-(1-METHYL-PIPERIDIN-4-YL)-METHANONE USING SAID COMPOUND, AND USE OF SAID COMPOUND IN THE PREPARATION OF LASMIDITAN". . . Retrieved 2021/01/23.
• 2、 -. "Synthesis method of 2-amino-6-(1-alkyl piperidine-4-carbonyl)pyridine compound". . . Retrieved 2020/05/01.