5-Bromo-2-(trifluoromethoxyl)benzonitrile

Base Information

• Chemical Name: 5-Bromo-2-(trifluoromethoxyl)benzonitrile
• CAS No.: 1210906-15-2
• Molecular Formula: C8H3BrF3NO
• Molecular Weight: 266.017
• Hs Code.: 2926909090
• Mol file: 1210906-15-2.mol

Synonyms:2-(Trifluoromethoxy)-5-bromobenzonitrile;5-Bromo-2-(trifluoromethoxy)benzonitrile

Chemical Property of 5-Bromo-2-(trifluoromethoxyl)benzonitrile

Chemical Property:

• Boiling Point: 244℃
• Flash Point: 101℃
• PSA: 33.02000
• Density: 1.75
• LogP: 3.21938
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-(trifluoromethoxy)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-2-(trifluoromethoxyl)benzonitrile

There total 1 articles about 5-Bromo-2-(trifluoromethoxyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-bromo-2-(trifluoromethoxy)benzaldehyde (923281-52-1) → 5-bromo-2-(trifluoromethoxy)benzonitrile (1210906-15-2)

Guidance literature:

With hydroxylamine hydrochloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 100 ℃; for 8h;

Reference yield: 95.0%

potassium trifluoro(methoxymethyl)boranuide (910251-11-5) + 5-bromo-2-(trifluoromethoxy)benzonitrile (1210906-15-2) → 5-(methoxymethyl)-2-(trifluoromethoxy)benzonitrile

Guidance literature:

With caesium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; ruphos; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.1c00483

Reference yield: 72.0%

5-bromo-2-(trifluoromethoxy)benzonitrile (1210906-15-2) + (R)-tert-butyl 2-methylpiperazine-1-carboxylate (170033-47-3) → 5-[(3R)-3-methylpiperazin-1-yl]-2-(trifluoromethoxy)benzonitrile

Guidance literature:

5-bromo-2-(trifluoromethoxy)benzonitrile; (R)-tert-butyl 2-methylpiperazine-1-carboxylate; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 ℃;

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

5-bromo-2-(trifluoromethoxy)benzaldehyde

Refernces

• 1、 -. "PIPERIDINYL PYRAZOLO-PYRIDINE DERIVATIVE CRYSTAL". Paragraph 0541 - 0543. . Retrieved 2016/10/10.