(S)-Morpholin-2-ylmethanol hydrochloride

Base Information

• Chemical Name: (S)-Morpholin-2-ylmethanol hydrochloride
• CAS No.: 1313584-92-7
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.609
• Hs Code.: 2934999090
• European Community (EC) Number: 835-875-5
• DSSTox Substance ID: DTXSID90703896
• Mol file: 1313584-92-7.mol

Synonyms:1313584-92-7;(S)-Morpholin-2-ylmethanol hydrochloride;(S)-(2-Hydroxymethyl)morpholine hydrochloride;(S)-2-HYDROXYMETHYLMORPHOLINE HYDROCHLORIDE;(2S)-morpholin-2-ylmethanol hydrochloride;(S)-2-HYDROXYMETHYLMORPHOLINE HCL;[(2S)-morpholin-2-yl]methanol;hydrochloride;2-MorpholineMethanol, hydrochloride, (2S)-;(S)-2-Hydroxymethylmorpholine, HCl;[(2S)-morpholin-2-yl]methanol hydrochloride;2-Morpholinemethanol, hydrochloride (1:1), (2S)-;(S)-2-Hydroxymethyl-morpholine hydrochloride;(S)-morpholin-2-ylmethanol-HCl;(S)-2-Morpholinemethanol HCl;MFCD13191722;(S)-Morpholin-2-yl-methanol hydrochloride;SCHEMBL15573075;(S)-morpholin-2-ylmethanol HCl;DTXSID90703896;NBGXGDBTUJNTKJ-JEDNCBNOSA-N;AMY21771;SC3851;(S)-2-(Hydroxymethyl)morpholine HCl;AKOS015909426;CS-W003855;GS-4126;(S)-Morpholin-2-ylmethanolhydrochloride;(S)morpholin-2-ylmethanol hydrochloride;AS-80174;(S)--2-Hydroxymethylmorpholine hydrochloride;EN300-175487;A848980;[(2S)-Morpholin-2-yl]methanol--hydrogen chloride (1/1)

Chemical Property of (S)-Morpholin-2-ylmethanol hydrochloride

Chemical Property:

• PSA: 41.49000
• LogP: 0.09790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 67.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-2-Hydroxymethylmorpholine,hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)CO.Cl
• Isomeric SMILES: C1CO[C@@H](CN1)CO.Cl
• Uses: (S)-2-Hydroxymethylmorpholine, HCl

Technology Process of (S)-Morpholin-2-ylmethanol hydrochloride

There total 2 articles about (S)-Morpholin-2-ylmethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate (135065-76-8) → (S)-2-(hydroxymethyl)morpholine hydrochloride (1313584-92-7,144053-98-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 2h;

Reference yield: 94.0%

(2S)-4-(p-tolylsulfinyl)-2-[(trityloxy)methyl]morpholine (1313484-80-8) → (S)-2-(hydroxymethyl)morpholine hydrochloride (1313584-92-7,144053-98-5)

Guidance literature:

(2S)-4-(p-tolylsulfinyl)-2-[(trityloxy)methyl]morpholine; With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With methanol; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/ejoc.201100337

Reference yield: 100.0%

(S)-2-(hydroxymethyl)morpholine hydrochloride (1313584-92-7,144053-98-5) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate (500702-97-6)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 25 ℃; for 6h;

upstream raw materials:

(2S)-4-(p-tolylsulfinyl)-2-[(trityloxy)methyl]morpholine

tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

Downstream raw materials:

(S)-morpholin-2-ylmethanol

benzyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

Refernces

• 1、 -. "COMPOUNDS". Paragraph 44. . Retrieved 2018/09/08.
• 2、 Fritz, Sven P.,Mumtaz, Amara,Yar, Muhammad,McGarrigle, Eoghan M.,Aggarwal, Varinder K.. "Sulfinamides as highly effective amine protecting groups and their use in the conversion of Amino alcohols into morpholines". experimental part. p. 3156 - 3164. Retrieved 2011/06/28.