Antienite

Base Information

• Chemical Name: Antienite
• CAS No.: 5029-05-0
• Molecular Formula: C9H8N2S2
• Molecular Weight: 208.308
• Mol file: 5029-05-0.mol

Synonyms:Antienite;6-(2-thienyl)-5,6-dihydroimidazo[2,1-b]thiazole;6-thiophen-2-yl-5,6-dihydroimidazo[2,1-b][1,3]thiazole

Chemical Property of Antienite

Chemical Property:

• Vapor Pressure: 2.12E-05mmHg at 25°C
• Refractive Index: 1.813
• Boiling Point: 361.1°C at 760 mmHg
• Flash Point: 172.2°C
• PSA: 73.77000
• Density: 1.52g/cm³
• LogP: 1.70230

Purity/Quality:

95-99% ^*data from raw suppliers

ANTIENITE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Therapeutic Function: Anthelmintic

Technology Process of Antienite

There total 4 articles about Antienite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(2-imino-thiazol-3-yl)-1-thiophen-2-yl-ethanol (6691-91-4) → Antienit, 5,6-Dihydro-6-(2-thienyl)-imidazo<2,1-b>thiazol (5719-88-0,5029-05-0)

Guidance literature:

With thionyl chloride; In dichloromethane; at 4 ℃; for 2.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2011.02.089

Reference yield:

2-(2-imino-thiazol-3-yl)-1-thiophen-2-yl-ethanone (5068-68-8) → Antienit, 5,6-Dihydro-6-(2-thienyl)-imidazo<2,1-b>thiazol (5719-88-0,5029-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 10 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 2.5 h / 4 °C / Inert atmosphere; Reflux

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.02.089

Reference yield:

2-amino-3-(2-oxo-2-phenyl-ethyl)-thiazolium; bromide (116923-07-0) → Antienit, 5,6-Dihydro-6-(2-thienyl)-imidazo<2,1-b>thiazol (5719-88-0,5029-05-0)

Guidance literature:

With hydrogen bromide; for 0.0833333h; Heating;

DOI:10.1021/jm00322a023

upstream raw materials:

2-amino-3-(2-oxo-2-phenyl-ethyl)-thiazolium; bromide

2-(2-imino-thiazol-3-yl)-1-thiophen-2-yl-ethanone

2-(2-imino-thiazol-3-yl)-1-thiophen-2-yl-ethanol

Refernces