3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride

Base Information

• Chemical Name: 3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride
• CAS No.: 376591-97-8
• Molecular Formula: C13H11NO3.ClH
• Molecular Weight: 265.696
• Hs Code.: 2922509090
• Mol file: 376591-97-8.mol

Synonyms:3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride;3'-amino-2'-hydroxybiphenyl-3-carboxylic acid,hydrochloride salt;3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrochloride;

Chemical Property of 3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride

Chemical Property:

• PSA: 83.55000
• LogP: 3.72280
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3'-Amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride

There total 6 articles about 3'-aMino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride (376591-97-8)

Guidance literature:

Reference yield: 95.0%

2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid (376591-95-6) → 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride (376591-97-8)

Guidance literature:

2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid; With palladium on activated charcoal; hydrazine hydrate; In methanol; for 3h; Reflux;

With hydrogenchloride; In water; for 0.5h; pH=5;

Reference yield:

2’-benzyloxy-3’-nitrobiphenyl-3-carboxylic acid → 3'-amino-2'-hydroxy-1,1'-biphenyl-3-carboxylic acid hydrochloride (376591-97-8)

Guidance literature:

2’-benzyloxy-3’-nitrobiphenyl-3-carboxylic acid; With 5%-palladium/activated carbon; hydrogen; sodium hydroxide; In methanol; water; at 20 ℃; for 2h; under 3000.3 Torr;

With hydrogenchloride; In methanol; water;

upstream raw materials:

1-bromo-3-nitro-2-[(phenylmethyl)oxy]benzene

3-Carboxyphenylboronic acid

2'-hydroxy-3'-nitro-biphenyl-3-carboxylic acid

2-hydroxybromobenzene

Downstream raw materials:

3’-{N’-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-di-hydropyrazol-4-ylidene]hydrazino}-2’-hydroxybiphenyl-3-carboxylic acid

3'-{N'-[3-methyl-5-oxo-1-(4-trifluoromethylpyrimidin-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid

3'-{N'-[3-chloro-1-(3,4-dimethylphenyl)-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid

3’-{N’-[1-(3,4-dimethylphenyl)-3,5-dioxo-1,5-di-hydropyrazol-4-ylidene]hydrazino}-2’-hydroxybiphenyl-3-carboxylic acid

Refernces

• 1、 -. "Preparation method of Eltrombopag key intermediate 3'-amino-2'-hydroxybiphenyl-3-carboxylic acid". Paragraph 0019; 0021; 0022. . Retrieved 2019/11/20.
• 2、 -. "Thrombopoietin mimetics". Page 18. . Retrieved 2008/06/13.