Trans-4-Hydroxy-L-proline Hydrochloride

Base Information

• Chemical Name: Trans-4-Hydroxy-L-proline Hydrochloride
• CAS No.: 32968-78-8
• Molecular Formula: C5H10ClNO3
• Molecular Weight: 167.592
• Mol file: 32968-78-8.mol

Synonyms:TRANS-4-HYDROXY-L-PROLINE HYDROCHLORIDE;(4R)-hydroxy-L-proline hydrochloride;(2S,4R)-4-Hydroxy-proline hydrochloride;trans-4-hydroxy-L-proline , hydrochloride;trans-4-Hydroxy-L-prolin, Hydrochlorid;(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride;(4R)-hydroxyproline hydrochloride;

Chemical Property of Trans-4-Hydroxy-L-proline Hydrochloride

Chemical Property:

• PSA: 69.56000
• LogP: -0.07540
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylicacidhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trans-4-Hydroxy-L-proline Hydrochloride

There total 3 articles about Trans-4-Hydroxy-L-proline Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride (32968-78-8,441067-49-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: lithium borohydride / tetrahydrofuran / 20 °C

3: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium borohydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid (364750-80-1,871727-77-4) → (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride (32968-78-8,441067-49-8)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield:

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate (138512-74-0) → (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid hydrochloride (32968-78-8,441067-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 20 °C

2: hydrogenchloride / diethyl ether

With hydrogenchloride; lithium borohydride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-methylpyrrolidine-1,2-dicarboxylate

(2S,4R)-1-[(tert-butoxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid

L-4-hydroxyproline methyl ester hydrochloride

Downstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

(2S, 4R)-N-(2-azidobenzoyl)-4-hydroxypyrrolidine-2-carboxylic acid

C₁₄H₁₆N₄O₆

C₂₀H₂₀N₄O₆

Refernces