6-Bromo-3,4-dihydro-2h-pyrido[3,2-B][1,4]oxazine

Base Information

• Chemical Name: 6-Bromo-3,4-dihydro-2h-pyrido[3,2-B][1,4]oxazine
• CAS No.: 959992-62-2
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.049
• Hs Code.: 2934999090
• Mol file: 959992-62-2.mol

Synonyms:6-bromo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]oxazine;;

Chemical Property of 6-Bromo-3,4-dihydro-2h-pyrido[3,2-B][1,4]oxazine

Chemical Property:

• PSA: 34.15000
• LogP: 1.78640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% purity ^*data from raw suppliers

6-?Bromo-?3,?4-?dihydro-2H-?Pyrido[3,?2-?b]?-?1,?4-?oxazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-?Bromo-?3,?4-?dihydro-2H-?Pyrido[3,?2-?b]?-?1,?4-?oxazine is a starting material and useful building blocks of various pharmaceuticals.

Technology Process of 6-Bromo-3,4-dihydro-2h-pyrido[3,2-B][1,4]oxazine

There total 9 articles about 6-Bromo-3,4-dihydro-2h-pyrido[3,2-B][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (337463-88-4) → 6-bromo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]oxazine (959992-62-2)

Guidance literature:

6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one; With borane-THF; In tetrahydrofuran; at 90 ℃; for 1.5h;

With methanol; In tetrahydrofuran; at 90 ℃; for 0.333333h;

Reference yield: 55.0%

6-bromo-3-(2-bromoethoxy)-2-nitropyridine (959992-61-1) → 6-bromo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]oxazine (959992-62-2)

Guidance literature:

6-bromo-3-(2-bromoethoxy)-2-nitropyridine; With iron; acetic acid; at 90 ℃; for 5h;

With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 90 ℃;

Reference yield:

C7H8Br2N2O (1303588-62-6) → 6-bromo-3,4-dihydro-2H-pyrido[3,2-b] [1,4]oxazine (959992-62-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃;

upstream raw materials:

6-bromo-3-(2-bromoethoxy)-2-nitropyridine

3-hydroxy-2-nitropyridine

6-bromo-2-nitropyridin-3-ol

C₇H₈Br₂N₂O

Downstream raw materials:

6-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

(2-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methanone

(2-(2,3-dihydroxypropoxy)pyridin-4-yl)(6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][l,4]oxazin-4(3H)-yl)methanone trifluoroacetate salt

pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Refernces

• 1、 -. "TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE". . . Retrieved 2013/12/03.
• 2、 -. "RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY". . . Retrieved 2011/07/30.