Desmopressin acetate

Base Information

• Chemical Name: Desmopressin acetate
• CAS No.: 62288-83-9
• Molecular Formula: C₂H₄O₂*C₄₆H₆₄N₁₄O₁₂S₂
• Molecular Weight: 1129.29
• Hs Code.: 2937190000
• European Community (EC) Number: 658-048-9
• UNII: 1K12647SFC
• DSSTox Substance ID: DTXSID4046864
• Wikidata: Q27252517
• NCI Thesaurus Code: C47475
• RXCUI: 42634
• ChEMBL ID: CHEMBL1200556
• Mol file: 62288-83-9.mol

Synonyms:1-Deamino-8-D-arginine Vasopressin;1-Desamino-8-arginine Vasopressin;Acetate, Desmopressin;Adiuretin;Adiuretin SD;Apo-Desmopressin;Arginine Vasopressin, Deamino;DDAVP;Deamino Arginine Vasopressin;Desmogalen;Desmopressin;Desmopressin Acetate;Desmopressin Monoacetate;Desmopressin Monoacetate, Trihydrate;Desmopressine Ferring;Desmospray;Desmotabs;Ferring, Desmopressine;Minirin;Minurin;Monoacetate, Desmopressin;Monoacetate, Trihydrate Desmopressin;Nocutil;Octim;Octostim;Trihydrate Desmopressin Monoacetate;Vasopressin, 1-Deamino-8-D-arginine;Vasopressin, 1-Desamino-8-arginine;Vasopressin, Deamino Arginine

Chemical Property of Desmopressin acetate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 170-172°C
• Boiling Point: 1667.7°C at 760 mmHg
• Flash Point: 962.4°C
• PSA: 523.31000
• Density: 1.56 g/cm³
• LogP: 1.61440
• Storage Temp.: -20?C Freezer
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 19
• Exact Mass: 1128.44808525
• Heavy Atom Count: 78
• Complexity: 2070

Purity/Quality:

98.5% ^*data from raw suppliers

DesmopressinAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)O.C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
• Isomeric SMILES: CC(=O)O.C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N
• Recent ClinicalTrials: Adding Desmopressin to Tamsulosin for Treatment of BPH
• Recent EU Clinical Trials: Implementation of pharmacokinetic-guided dosing of DDAVP and VWF-containing concentrates in von Willebrand disease
• Uses: Synthetic analog of vasopressin. Antidiuretic; hemostatic Synthetic analog of Vasopressin with antidiuretic activity and decreased pressor effects. Improves hemostatsis by increasing plasma levels of von Willebrand factor, factor VIII and tissue plasminogen activator. Antidiuretic; hemostatic.

Technology Process of Desmopressin acetate

There total 2 articles about Desmopressin acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

desmopressin trifluoroacetate + acetic acid (64-19-7,77671-22-8) → desmopressin acetate (16789-98-3,62288-83-9)

Guidance literature:

Reference yield:

→ desmopressin acetate (16789-98-3,62288-83-9)

Guidance literature:

upstream raw materials:

acetic acid

Refernces

• 1、 -. "Counterion exchange process for peptides". Page/Page column 10. . Retrieved 2008/06/13.